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The B-cell antigen receptor of the five immunoglobulin classes

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Abstract

Several proteins associate with surface IgM to form the antigen receptor. We show that just two, the α and β associated chains, are sufficient to reconstitute an IgM surface receptor in fibroblasts. Contrary to expectation, α common a chain associ-ates with all five immunoglobulin classes. We pro-pose that B-cell antigen receptors consist of a common α/β heterodimer associated with each immunoglobulin class. But the classes differ both in the glycosylation of their associated α chain and in their dependence on α/β for surface transport.

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Authors and Affiliations

  1. MRC Laboratory of Molecular Biology, Hills Road, Cambridge, CB2 2QH, UK

    Ashok R. Venkitaraman, Gareth T. Williams, Piona Dariavach & Michael S. Neuberger

  2. Laboratoire d'lmmunogénétique Moléculaire, Université de Montpellier II, France

    Piona Dariavach

Authors
  1. Ashok R. Venkitaraman
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  2. Gareth T. Williams
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  3. Piona Dariavach
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  4. Michael S. Neuberger
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Venkitaraman, A., Williams, G., Dariavach, P. et al. The B-cell antigen receptor of the five immunoglobulin classes. Nature 352, 777–781 (1991). https://doi.org/10.1038/352777a0

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  • DOI: https://doi.org/10.1038/352777a0

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