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Male development of chromosomally female mice transgenic for Sry

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Abstract

The initiation of male development in mammals requires one or more genes on the Y chromosome. A recently isolated gene, termed SRY in humans and Sry in mouse, has many of the genetic and biological properties expected of a Y-located testis-determining gene. It is now shown that Sry on a 14-kilobase genomic DNA fragment is sufficient to induce testis differentiation and subsequent male development when introduced into chromosomally female mouse embryos.

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Author notes

  1. Peter Goodfellow: Human Molecular Genetics Laboratory, Imperial Cancer Research Fund, PO Box 123, Lincoln's Inn Fields, London WC2A 3PX, UK

Authors and Affiliations

  1. Laboratory of Eukaryotic Molecular Genetics, MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London, NW7 1AA, UK

    Peter Koopman, John Gubbay, Nigel Vivian, Peter Goodfellow & Robin Lovell-Badge

Authors
  1. Peter Koopman
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  2. John Gubbay
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  3. Nigel Vivian
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  4. Peter Goodfellow
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  5. Robin Lovell-Badge
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Koopman, P., Gubbay, J., Vivian, N. et al. Male development of chromosomally female mice transgenic for Sry. Nature 351, 117–121 (1991). https://doi.org/10.1038/351117a0

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  • DOI: https://doi.org/10.1038/351117a0

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