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Achilles' heel of cancer?

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The p53 protein is inactivated in most human cancers. One outcome is a defect in controlling cell division. Might a virus that exploits this defect prove useful in treating cancer?

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Figure 1: The strategy used by Raj et al.3 to kill cells that lack p53.

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Authors and Affiliations

  1. Howard Hughes Medical Institute and Johns Hopkins Oncology Center, Baltimore, 21231, Maryland, USA

    Bert Vogelstein & Kenneth W. Kinzler

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  1. Bert Vogelstein
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  2. Kenneth W. Kinzler
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Vogelstein, B., Kinzler, K. Achilles' heel of cancer?. Nature 412, 865–866 (2001). https://doi.org/10.1038/35091170

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