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Swallowing dynein: a missing link in RNA localization?

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Abstract

Localization of bicoid messenger RNA to the anterior cortex of the developing oocyte is essential for correct anterior-posterior patterning of the Drosophila embryo. It now seems that the Swallow protein functions as an adaptor, bridging bicoid mRNA to dynein, a molecular motor that would transport the complex anteriorly along microtubules.

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Figure 1: Asymmetric localization of bicoid mRNA in wild-type but not swa-mutant Drosophila oocytes.
Figure 2: Model for bicoid mRNA localization to the anterior cortex of the oocyte, based on the results of Schnorrer et al.5

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Authors and Affiliations

  1. Department of Genetics, the University of Minnesota, Cell and Developmental Biology, 6-160 Jackson Hall, 321 Church Street SE, Minneapolis, 55455, Minnesota, USA

    Tom Hays

  2. the CNRS Centre de Génétique Moléculaire, Ave de la Terrasse, Gif-sur-Yvette, 91198 , France

    Roger Karess

Authors
  1. Tom Hays
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  2. Roger Karess
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Correspondence to Roger Karess.

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Hays, T., Karess, R. Swallowing dynein: a missing link in RNA localization? . Nat Cell Biol 2, E60–E62 (2000). https://doi.org/10.1038/35008687

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