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Cyclin synthesis drives the early embryonic cell cycle

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Abstract

We have produced extracts of frog eggs that can perform multiple cell cycles in vitro. Destruction of the endogenous messenger RNA arrests the extracts in interphase. The addition of exogenous cyclin mRNA is sufficient to produce multiple cell cycles. The newly synthesized cyclin protein accumulates during each interphase and is degraded at the end of each mitosis.

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Authors and Affiliations

  1. Department of Biochemistry and Biophysics, School of Medicine, University of California at San Francisco, San Francisco, California, 94143–0448, USA

    Andrew W. Murray & Marc W. Kirschner

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  1. Andrew W. Murray
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  2. Marc W. Kirschner
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Murray, A., Kirschner, M. Cyclin synthesis drives the early embryonic cell cycle. Nature 339, 275–280 (1989). https://doi.org/10.1038/339275a0

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  • DOI: https://doi.org/10.1038/339275a0

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