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Autoregulated instability of β-tubulin mRNAs by recognition of the nascent amino terminus of βtubulin

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Abstract

Tubulin synthesis in animal cells is controlled by an autoregulatory mechanism that modulates the stability of polysome-bound tubulin messenger RNAs. The β-tubulin RNAs are selectively targeted as substrates for destabilization not through the recognition of specific RNA sequences, but rather through co-translational recognition of the amino-terminal β-tubulin tetrapeptide after its emergence from the ribosome. This motif is likely to be used in other systems where RNA degradation is coupled to ribosome attachment and translation.

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Authors and Affiliations

  1. Department of Biological Chemistry, Johns Hopkins University School of Medicine, Baltimore, Maryland, 21205, USA

    Tim J. Yen, Paula S. Machlin & Don W. Cleveland

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  1. Tim J. Yen
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  2. Paula S. Machlin
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  3. Don W. Cleveland
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Yen, T., Machlin, P. & Cleveland, D. Autoregulated instability of β-tubulin mRNAs by recognition of the nascent amino terminus of βtubulin. Nature 334, 580–585 (1988). https://doi.org/10.1038/334580a0

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