Abstract
Within the substantia nigra, the dendrites of dopaminergic neurons that project to the striatum appear to play an active and non-classical role in the physiology of the neuron in that they release transmitter and protein1, but little is known of the factors controlling release of substances from these dendrites. In this study, we show that 5-hydroxytryptamine, which is contained in afferent fibres to the substantia nigra, is present in terminals making direct synaptic contact with dopaminergic neurons and also that it has a site-dependent, receptor-mediated, facilitatory effect on a specific dendritic calcium-dependent potential in nigrostriatal neurons in vitro. The ionic and spatial features of this response, which is insensitive to blockade by three different K+-channel antagonists, could correspond to those underlying the dendritic release of dopamine.
Similar content being viewed by others
References
Greenfield, S. A. Neurochem. Int. 7, 887–901 (1985).
Glowinski, J. & Cheramy, A. in Chemical Transmission: 75 Years (eds Stjarne, L., Hedquist, P., Lagercrantz, H. & Wennmalm, A.) 127–149 (Academic, NY, 1981).
Llinas, R., Greenfield, S. A. & Jahnsen, H. Brain Res. 294, 127–132 (1984).
Steinbusch, H. W. M. Neuroscience 6, 557–618 (1981).
Taylor, S. J., Bartlett, M. J. & Greenfield, S. A. Neuropharmacology 27, 507–514 (1988).
Levey, A. I. et al. J. Histochem. Cytochem. 34, 1449–1457 (1986).
Bolarn, J. P. et al. Brain Res. 397, 279–289 (1986).
Roberts, M. T. T. & Straughan, D. W. J. Physiol. 193, 269–294 (1967).
Jahnsen, H. Prog. Neurobiol. 27, 351–372 (1986).
Sielgelbaum, S. A., Camardo, J. S. & Kandel, E. R. Nature 299, 413–417 (1982).
Halliwell, J. V. & Adams, P. R. Brain Res. 250, 71–92 (1982).
Colino, A. & Halliwell, J. V. Nature 328, 73–77 (1987).
Pellmar, T. C. & Carpenter, D. O. J. Neurophysiol. 44, 423–439 (1980).
Dray, A., Gonye, T. J., Oakley, N. R. & Tanner, T. Brain Res. 113, 45–57 (1976).
Soubrie, P., Reisine, T. & Glowinski, J. Neuroscience 13, 605–625 (1984).
Llinas, R. & Sugimori, M. J. Physiol. 305, 171–195 (1980).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Nedergaard, S., Bolam, J. & Greenfield, S. Facilitation of a dendritic calcium conductance by 5-hydroxytryptamine in the substantia nigra. Nature 333, 174–177 (1988). https://doi.org/10.1038/333174a0
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1038/333174a0
- Springer Nature Limited
This article is cited by
-
Perinatal interference with the serotonergic system affects VTA function in the adult via glutamate co-transmission
Molecular Psychiatry (2021)
-
Opponency Revisited: Competition and Cooperation Between Dopamine and Serotonin
Neuropsychopharmacology (2011)
-
Dopamine D1 Receptor Gene Expression Studies in Unilateral 6-Hydroxydopamine-Lesioned Parkinson’s Rat: Effect of 5-HT, GABA, and Bone Marrow Cell Supplementation
Journal of Molecular Neuroscience (2010)
-
Nonselective cation channels are essential for maintaining intracellular Ca2+ levels and spontaneous firing activity in the midbrain dopamine neurons
Pflügers Archiv - European Journal of Physiology (2007)
-
Mechanisms intrinsic to 5‐HT2B receptor‐induced potentiation of NMDA receptor responses in frog motoneurones
British Journal of Pharmacology (2004)