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A novel potent vasoconstrictor peptide produced by vascular endothelial cells

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Abstract

An endothelium-derived 21-residue vasoconstrictor peptide, endothelin, has been isolated, and shown to be one of the most potent vasoconstrictors known. Cloning and sequencing of preproendothelin complementary DNA shows that mature endothelin is generated through an unusual proteolytic processing, and regional homologies to a group of neurotoxins suggest that endothelin is an endogenous modulator of voltage-dependent ion channels. Expression of the endothelin gene is regulated by several vasoactive agents, indicating the existence of a novel cardiovascular control system.

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Author information

Author notes

  1. Hiroki Kurihara

    Present address: Third Department of Internal Medicine, University of Tokyo, Hongo, Tokyo, 113, Japan

  2. Mieko Kobayashi and Youji Mitsui: Fermentation Research Institute, Agency of Industrial Science and Technology, Tsukuba, Ibaraki 305, Japan

  3. Yoshio Yazaki: Third Department of Internal Medicine, University of Tokyo, Hongo, Tokyo 113, Japan

  4. Tomoh Masaki: To whom correspondence should be addressed.

Authors and Affiliations

  1. Institute of Basic Medical Sciences, University of Tsukuba, Tsukuba, Ibaraki, 305, Japan

    Masashi Yanagisawa, Hiroki Kurihara, Sadao Kimura, Yoko Tomobe, Mieko Kobayashi, Youji Mitsui, Yoshio Yazaki, Katsutoshi Goto & Tomoh Masaki

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  1. Masashi Yanagisawa
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  2. Hiroki Kurihara
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Yanagisawa, M., Kurihara, H., Kimura, S. et al. A novel potent vasoconstrictor peptide produced by vascular endothelial cells. Nature 332, 411–415 (1988). https://doi.org/10.1038/332411a0

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