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Self-tolerance eliminates T cells specific for Mls-modified products of the major histocompatibility complex

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Abstract

In mice the product of the Mlsa locus is an unusual antigen capable of interaction with certain products of the major histocompatibility locus (MHC) to form a ligand for a large portion of the T-cell α/β receptor repertoire, including nearly all receptors that use Vβ8.1. The presence of Mlsa/ MHC during T-cell development results in the deletion of T cells that express Vβ8.1 documenting the importance of clonal deletion in establishing tolerance to self antigens.

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References

  1. Babbitt, B., Allen, P., Matsueda, G., Haber, E. & Unanue, E. Nature 317, 359–361 (1985).

    Article  ADS  CAS  Google Scholar 

  2. Buus, S., Sette, A., Colon, S., Jenis, D. & Grey, H. Cell 47, 1071–1077 (1986).

    Article  CAS  Google Scholar 

  3. Zinkernagel, R. & Doherty, P. Nature 251, 547–548 (1974).

    Article  ADS  CAS  Google Scholar 

  4. Bevan, M. et al. Immun. Reviews 42, 1–270 (1978).

    Article  Google Scholar 

  5. Bjorkman, P. et al. Nature 329, 506–512 (1987).

    Article  ADS  CAS  Google Scholar 

  6. Bjorkman, P. et al. Nature 329, 512–518 (1987).

    Article  ADS  CAS  Google Scholar 

  7. Born, W. et al. J. Immun. 138, 999–1008 (1987).

    CAS  PubMed  Google Scholar 

  8. McDuffie, M., Born, W., Marrack, P. & Kappler, J. Proc. natn. Acad. Sci. U.S.A 83, 8728–8733 (1986).

    Article  ADS  CAS  Google Scholar 

  9. Kruisbeek, A. et al. J. exp. Med. 161, 1029–1047 (1985).

    Article  CAS  Google Scholar 

  10. Bevan, M. Nature 269, 417–419 (1977).

    Article  ADS  CAS  Google Scholar 

  11. Zinkernagel, R. et al. J. exp. Med. 147, 882–896 (1978).

    Article  CAS  Google Scholar 

  12. Billingham, R., Brent, L. & Medawar, P. Nature 172, 603–606 (1956).

    Article  ADS  Google Scholar 

  13. Festenstein, H. Transplant. Rev. 15, 62–88 (1973).

    CAS  PubMed  Google Scholar 

  14. Festenstein, H. Transplantation 18, 555–557 (1974).

    Article  CAS  Google Scholar 

  15. Festenstein, H., Bishop, C. & Taylor, B. Immunogenetics 5, 357–361 (1977).

    Article  Google Scholar 

  16. Janeway, C., Lerner, E., Jason, J. & B. Jones Immunogenetics 10, 481–497 (1980).

    Article  Google Scholar 

  17. Jones, B. & Janeway, C. Immunogenetics 16, 243–256 (1982).

    Article  CAS  Google Scholar 

  18. Lynch, D., Gress, R., Needleman, B., Rosenberg, S. & Hodes, R. J. Immun. 134, 2071–2078 (1985).

    CAS  PubMed  Google Scholar 

  19. Webb, S., Molnar-Kimber, K., Jennifer, B., Sprent, J. & Wilson, D. J. exp. Med. 154, 1970–1974 (1981).

    Article  CAS  Google Scholar 

  20. Webb, S. et al. J. exp. Med. 161, 269–274 (1985).

    Article  CAS  Google Scholar 

  21. Staerz, U., Rammensee, H., Benedetto, J. & Bevan, M. J. Immun. 134, 3994–4000 (1985).

    CAS  Google Scholar 

  22. Behlke, M. et al. J. exp. Med. 165, 257–262 (1987).

    Article  CAS  Google Scholar 

  23. Haskins, K. et al. J. exp. Med. 160, 452–471 (1984).

    Article  CAS  Google Scholar 

  24. Staerz, U. & Bevan, M. in Molecular Biology of the Immune System (eds Streilein, J., Ahmad, F., Black, S., Blomberg, B. & Voellmy, R.) 61–64 (Cambridge University Press, Cambridge, 1985).

    Google Scholar 

  25. Kappler, J. et al. Cell 49, 263–271 (1987).

    Article  CAS  Google Scholar 

  26. Kappler, J., Roehm, N. & Marrack, P. Cell 49, 273–280 (1987).

    Article  CAS  Google Scholar 

  27. Roehm, N. et al. J. Immun. 135, 2176–2182 (1985).

    CAS  Google Scholar 

  28. Abe, R., Ryan, J. & R. Hodes, J. exp. Med. 165, 1113–1129 (1987).

    Article  CAS  Google Scholar 

  29. Click, R. et al. J. Immun. 139, 321–325 (1987).

    CAS  PubMed  Google Scholar 

  30. Taylor, B. in Genetic Variants and Strains of the Laboratory Mouse (ed. Green, M.) 397 (Fisher, Stuttgart, 1981).

    Google Scholar 

  31. Roehm, N. et al. Cell 38, 577–584 (1984).

    Article  CAS  Google Scholar 

  32. Glasebrook, A. & Fitch, F. J. exp. Med. 151, 876–895 (1980).

    Article  CAS  Google Scholar 

  33. Katz, M. & Janeway, C. J. Immun. 134, 2064–2070 (1985).

    CAS  PubMed  Google Scholar 

  34. Hasek, M. et al. Immun. Rev. 46, 1–86, 123–146 (1979).

    Article  Google Scholar 

  35. Allen, P., McKean, D., Beck, B., Sheffield, J. & Glimcher, L. J. exp. Med. 162, 1264–1274 (1985).

    Article  CAS  Google Scholar 

  36. Ogasawara, K., Maloy, W. & Schwartz, R. Nature 325, 450–452 (1987).

    Article  ADS  CAS  Google Scholar 

  37. Fink, P., Matis, L., McElligott, D., Bookman, M. & Hedrick, S. Nature 321, 219–226 (1986).

    Article  ADS  CAS  Google Scholar 

  38. Winoto, A. et al. Nature 324, 679–682 (1986).

    Article  ADS  CAS  Google Scholar 

  39. Kappler, J., Skidmore, B., White, J. & Marrack, P. J. exp. Med. 153, 1198–1214 (1981).

    Article  CAS  Google Scholar 

  40. Marrack, P. in Isolation, Characterization and Utilization of T-Lymphocyte Clones (eds Fathman, G. & Fitch, F.) 508–510 (Academic, New York, 1982).

    Google Scholar 

  41. Kranz, D., Sherman, D., Sitkovsky, M., Pasternack, M. & Eisen, H. Proc. natn. Acad. Sci. U.S.A. 81, 573–577 (1984).

    Article  ADS  CAS  Google Scholar 

  42. Kaye, J., Porcelli, S., Tite, J., Jones, B. & Janeway, C. J. exp. Med. 158, 836–856 (1983).

    Article  CAS  Google Scholar 

  43. White, J., Haskins, K., Marrack, P. & Kappler, J. (1983) J. Immun. 130, 1033–1037 (1983).

    CAS  PubMed  Google Scholar 

  44. Blackman, M. et al. Cell 47, 349–357 (1986).

    Article  CAS  Google Scholar 

  45. Endres, R., Marrack, P. & Kappler, J. (1983). J. Immun. 131, 1656–1662 (1983).

    CAS  PubMed  Google Scholar 

  46. Choi, H. et al. Proc. natn. Acad. Sci. U.S.A. 84, 1992–1996 (1987).

    Article  ADS  Google Scholar 

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Authors and Affiliations

  1. Howard Hughes Medical Institute and Division of Basic Immunology, Department of Medicine, National Jewish Center for Immunology and Respiratory Medicine, 1400 Jackson Street, Denver, Colorado, 80206, USA

    John W. Kappler, Janice White & Philippa C. Marrack

  2. Department of Microbiology and Immunology, University of Colorado Health Sciences Center, Denver, Colorado, 80206, USA

    John W. Kappler & Philippa C. Marrack

  3. Department of Medicine, University of Colorado Health Sciences Center, Denver, Colorado, 80206, USA

    John W. Kappler

  4. Department of Biochemistry, Biophysics and Genetics, University of Colorado Health Sciences Center, Denver, Colorado, 80206, USA

    Philippa C. Marrack

  5. Basel Institute for Immunology, Basel, Switzerland

    Uwe Staerz

Authors
  1. John W. Kappler
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  2. Uwe Staerz
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  3. Janice White
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  4. Philippa C. Marrack
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Kappler, J., Staerz, U., White, J. et al. Self-tolerance eliminates T cells specific for Mls-modified products of the major histocompatibility complex. Nature 332, 35–40 (1988). https://doi.org/10.1038/332035a0

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  • DOI: https://doi.org/10.1038/332035a0

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