Abstract
The calcium release channel from rabbit muscle sarcoplasmic reticulum (SR) has been purified and reconstituted as a functional unit in lipid bilayers. Electron microscopy reveals the four-leaf clover structure previously described for the 'feet9 that span the transverse tubule (T)-SR junction. Ca2+ release from the SR induced by T-system depolarization during excitation-contraction coupling in muscle may thus be effected through a direct association of the T-system with SR Ca22+-release channels.
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Anthony Lai, F., Erickson, H., Rousseau, E. et al. Purification and reconstitution of the calcium release channel from skeletal muscle. Nature 331, 315–319 (1988). https://doi.org/10.1038/331315a0
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DOI: https://doi.org/10.1038/331315a0
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