Skip to main content
SpringerLink
Log in

Expression of insulin-like growth factor-II transcripts in Wilms' tumour

  • Letter
  • Published:

From Nature

View current issue Submit your manuscript

Abstract

Wilms' tumour probably arises from embryonal kidney cells and occurs in both hereditary and sporadic forms1. Knudson and Strong have suggested that both forms of the disease are initiated by two mutational events2. In the case of the inherited form, cytogenetic evidence indicates that a germline deletion of chromosome band 11p13 may correspond to one of the two mutations3–5. DNA mapping evidence is consistent with the notion that the tumour susceptibility gene (Wg) on chromosome 11 is actually recessive6–9. Comings has proposed that the dominantly inherited tumours may arise by the inactivation or loss of a diploid pair of regulatory genes which normally suppress the expression of a structural transforming gene (Tg)10. It has recently been suggested that the N-myc oncogene may serve as a transforming gene in retinoblas-toma11, although no such gene has yet been identified in Wilms' tumour. We now report that in four cases of Wilms' tumour, insulin-like growth factor-II (IGF-II) transcripts are highly elevated compared with the adjacent normal kidney. In addition, we have mapped the gene for IGF-II to chromosome band 11p14.1, which is in the immediate vicinity of Wg. These findings suggest that IGF-II may be involved in the aetiology of Wilms' tumour.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Gonzalez-Crussi, F. (ed.) & Franklin, W. A. in Wilms' Tumour and Related Renal Neoplasms of Childhood, 7 (CRC Press, Boca Raton, 1984).

    Google Scholar 

  2. Knudson, A. G. Jr & Strong, L. C. J. natn. Cancer Inst. 48, 313–342 (1972).

    Google Scholar 

  3. Riccardi, V. M., Sujansky, E., Smith, A. C. & Francke, U. Pediatrics 61, 604–610 (1978).

    CAS  PubMed  Google Scholar 

  4. Francke, U., Holmes, L. B., Atkins, L. & Riccardi, V. M. Cytogenet. Cell Genet. 24, 185–192 (1979).

    Article  CAS  PubMed  Google Scholar 

  5. Yunis, J. J. & Ramsay, N. K. C. J. Pediat. 96, 1027–1030 (1980).

    Article  CAS  PubMed  Google Scholar 

  6. Koufos, A. et al. Nature 309, 170–172 (1984).

    Article  ADS  CAS  PubMed  Google Scholar 

  7. Orkin, S. H., Goldman, D. S. & Sallan, S. E. Nature 309, 172–174 (1984).

    Article  ADS  CAS  PubMed  Google Scholar 

  8. Reeve, A. E. et al. Nature 309, 174–176 (1984).

    Article  ADS  CAS  PubMed  Google Scholar 

  9. Fearon, E. R., Vogelstein, B. & Feinberg, A. P. Nature 309, 176–178 (1984).

    Article  ADS  CAS  PubMed  Google Scholar 

  10. Comings, D. E. Proc. natn. Acad. Sci. U.S.A. 70, 3324–3328 (1973).

    Article  ADS  CAS  Google Scholar 

  11. Lee, W. H., Murphree, A. L. & Benedict, W. F. Nature 309, 458–460 (1984).

    Article  ADS  CAS  PubMed  Google Scholar 

  12. Strobel, R. J., Riccardi, V. M., Ledbetter, D. H. & Hittner, H. M. Am. J. med. Genet. 7, 15–20 (1980).

    Article  CAS  PubMed  Google Scholar 

  13. de Martinville, B. & Francke, U. Nature 305, 641–643 (1983).

    Article  ADS  CAS  PubMed  Google Scholar 

  14. Hittner, H. M., Riccardi, V. M. & Francke, U. Ophthalmology 86, 1173–1183 (1979).

    Article  CAS  PubMed  Google Scholar 

  15. Bell, G. I. et al. Nature 310, 775–777 (1984).

    Article  ADS  CAS  PubMed  Google Scholar 

  16. Brissenden, J. E., Ullrich, A. & Francke, U. Nature 310, 781–784 (1984).

    Article  ADS  CAS  PubMed  Google Scholar 

  17. Tricoli, J. V., Rail, L. B., Scott, J., Bell, G. I. & Shows, T. B. Nature 310, 784–786 (1984).

    Article  ADS  CAS  PubMed  Google Scholar 

  18. Slater, R. M. & de Kraker, J. Cancer Genet. Cytogenet. 5, 237–245 (1982).

    Article  CAS  PubMed  Google Scholar 

  19. Narahara, K. et al. Hum. Genet. 66, 181–185 (1984).

    Article  CAS  PubMed  Google Scholar 

  20. Gardner, R. J. M., Grindley, R. M., Chewings, W. E. & Holdaway, M. D. H. Proc. Univ. Otago med. Sch. 61, 32–34 (1983).

    Google Scholar 

  21. Thiele, C. J., Reynolds, C. P. & Israel, M. A. Nature 313, 404–406 (1985).

    Article  ADS  CAS  PubMed  Google Scholar 

  22. Maniatis, T., Fritsch, E. F. & Sambrook, J. in Molecular Cloning, 202 (Cold Spring Harbor Laboratory, New York, 1982).

    Google Scholar 

  23. Huerre, C., Despoisse, S., Gilgenkrantz, S., Lenoir, G. M. & Junien, C. Nature 305, 638–641 (1983).

    Article  ADS  CAS  PubMed  Google Scholar 

  24. Jhanwar, S. C., Neel, B. G., Hayward, W. S. & Chaganti, R. S. K. Proc. natn. Acad. Sci. U.S.A. 80, 4794–4797 (1983).

    Article  ADS  CAS  Google Scholar 

  25. Harper, M. E., Ullrich, A. & Saunders, G. F. Proc. natn. Acad. Sci. U.S.A. 78, 4458–4460 (1981).

    Article  ADS  CAS  Google Scholar 

  26. Raizis, A. M., Becroft, D. M., Shaw, R. L. & Reeve, A. E. Hum. Genet. (in the press).

  27. Dulak, N. C. & Temin, H. M. J. cell. Physiol. 81, 153–160 (1973).

    Article  CAS  PubMed  Google Scholar 

  28. Nissley, S. P., Rechler, M. M., Moses, A. C., Short, P. A. & Podskalny, J. M. Endocrinology 101, 708–716 (1977).

    Article  CAS  PubMed  Google Scholar 

  29. Moses, A. C., Cohen, K. L., Johnsonbaugh, R. & Nissley, S. P. Clin. Endocr. Metab. 46, 937–946 (1978).

    Article  CAS  Google Scholar 

  30. Moses, A. C. et al. Proc. natn. Acad. Sci. U.S.A. 77, 3649–3653 (1980).

    Article  ADS  CAS  Google Scholar 

  31. Adams, S. O., Nissley, S. P., Handwerger, S. & Rechler, M. M. Nature 302, 150–153 (1983).

    Article  ADS  CAS  PubMed  Google Scholar 

  32. Rabin, M. et al. Cytogenet. Cell Genet. 38, 70–72 (1984).

    Article  CAS  PubMed  Google Scholar 

  33. Bernheim, A., Berger, R. & Szabo, P. Chromosoma 89, 163–167 (1984).

    Article  CAS  PubMed  Google Scholar 

  34. Chirgin, J. M., Przybyla, A. E., MacDonald, R. J. & Rutter, W. J. Biochemistry 18, 5294–5299 (1979).

    Article  Google Scholar 

  35. Rigby, P. W. J., Dieckmann, M., Rhodes, C. & Berg, P. J. biol. Chem. 113, 234–251 (1977).

    Google Scholar 

  36. Shih, C. & Weinberg, R. A. Cell 29, 161–169 (1982).

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Molecular Carcinogenesis Laboratory, Department of Biochemistry, University of Otago, PO Box 56, Dunedin, New Zealand

    Anthony E. Reeve, Michael R. Eccles, Richard J. Wilkins & Lynn J. Millow

  2. Chiron Corporation, 4560 Horton Street, Emeryville, California, 94608, USA

    Graeme I. Bell

Authors
  1. Anthony E. Reeve
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Michael R. Eccles
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Richard J. Wilkins
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Graeme I. Bell
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Lynn J. Millow
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Reeve, A., Eccles, M., Wilkins, R. et al. Expression of insulin-like growth factor-II transcripts in Wilms' tumour. Nature 317, 258–260 (1985). https://doi.org/10.1038/317258a0

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1038/317258a0

  • Springer Nature Limited

This article is cited by

Search

Navigation