Skip to main content
SpringerLink
Log in

Induction of c-fos gene and protein by growth factors precedes activation of c-myc

  • Article
  • Published:

From Nature

View current issue Submit your manuscript

Abstract

Stimulation of fibroblasts with serum or purified growth factors leads to a dramatic induction of expression of both c-fos mRNA and protein within a few minutes, followed by activation of c-myc. This suggests that c-fos induction is a primary event and the earliest known effect on gene expression by growth factors.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

Chapter © 2017

Chapter © 2014

References

  1. Waterfield, M. D. et al. Nature 304, 35–39 (1983).

    Article  CAS  ADS  PubMed  Google Scholar 

  2. Doolittle, R. F. et al. Science 221, 275–277 (1983).

    Article  CAS  ADS  PubMed  Google Scholar 

  3. Downard, J. et al. Nature 307, 521–527 (1984).

    Article  ADS  Google Scholar 

  4. Kelly, K. et al. Cell 35, 603–610 (1983).

    Article  CAS  PubMed  Google Scholar 

  5. Campisi, J. et al. Cell 36, 241–247 (1984).

    Article  CAS  PubMed  Google Scholar 

  6. Makino, R., Hayashi, K. & Sugimura, T. Nature 310, 697–698 (1984).

    Article  CAS  ADS  PubMed  Google Scholar 

  7. Armelin, H. A. et al. Nature 310, 655–660 (1984).

    Article  CAS  ADS  PubMed  Google Scholar 

  8. Quade, K. Virology 98, 461–465 (1979).

    Article  CAS  PubMed  Google Scholar 

  9. Curran, T. & Teich, N. M. Virology 116, 221–235 (1982).

    Article  CAS  PubMed  Google Scholar 

  10. Curran, T., Van Beveren, C., Ling, N. & Verma, I. M. Molec. cell Biol. (in the press).

  11. Curran, T., Miller, A. D., Zokas, L. & Verma, I. M. Cell 36, 259–268 (1984).

    Article  CAS  PubMed  Google Scholar 

  12. Miller, A. D., Curran, T. & Verma, I. M. Cell 36, 51–60 (1984).

    Article  CAS  PubMed  Google Scholar 

  13. Curran, T. & Verma, I. M. Virology 135, 218–228 (1984).

    Article  CAS  PubMed  Google Scholar 

  14. Müller, R., Verma, I. M. & Adamson, E. D. EMBO J. 2, 679–684 (1983).

    Article  PubMed  PubMed Central  Google Scholar 

  15. Müller, R., Müller, D. & Guilbert, L. EMBO J. 3, 1887–1890 (1984).

    Article  PubMed  PubMed Central  Google Scholar 

  16. Gonda, T. J. & Metcalf, D. Nature 210, 249–251 (1984).

    Article  ADS  Google Scholar 

  17. Müller, R. & Wagner, E. F. Nature 311, 438–442 (1984).

    Article  ADS  PubMed  Google Scholar 

  18. Johnson, L. K., Baxter, J. D., Vlodavsky, I. & Gospodarowicz, D. Proc. natn. Acad. Sci. U.S.A. 77, 394–398 (1980).

    Article  CAS  ADS  Google Scholar 

  19. Benweniste, R. et al. Clin. Endocr. Metab. 46, 169–179 (1978).

    Article  Google Scholar 

  20. Greenberg, M. E. & Ziff, E. B. Nature 311, 433–438 (1984).

    Article  CAS  ADS  PubMed  Google Scholar 

  21. Müller, R. et al. Molec. cell Biol. 3, 1062–1069 (1983).

    Article  PubMed  PubMed Central  Google Scholar 

  22. Curran, T. et al. J. Virol. 44, 674–682 (1982).

    CAS  PubMed  PubMed Central  Google Scholar 

  23. Ellis, R. et al. J. Virol. 36, 408–420 (1980).

    CAS  PubMed  PubMed Central  Google Scholar 

  24. Shen-Ong, G. L. C., Keath, E. J., Piccoli, S. P. & Cole, M. D. Cell 31, 443–452 (1982).

    Article  CAS  PubMed  Google Scholar 

  25. Müller, R. & Müller, D. EMBO J. 3, 1121–1127 (1984).

    Article  PubMed  PubMed Central  Google Scholar 

  26. Müller, R., Tremblay, J. M., Adamson, E. D. & Verma, I. M. Nature 304, 454–456 (1983).

    Article  ADS  PubMed  Google Scholar 

  27. Curran, T. & Teich, N. M. J. Virol. 42, 114–122 (1982).

    CAS  PubMed  PubMed Central  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. European Molecular Biology Laboratory, Postfach 10.2209, D-6900, Heidelberg, FRG

    Rolf Müller, Rodrigo Bravo & Jean Burckhardt

  2. Department of Molecular Genetics, Roche Research Center, Hoffman-LaRoche Inc., Nutley, New Jersey, 07110, USA

    Tom Curran

Authors
  1. Rolf Müller
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Rodrigo Bravo
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Jean Burckhardt
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Tom Curran
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Müller, R., Bravo, R., Burckhardt, J. et al. Induction of c-fos gene and protein by growth factors precedes activation of c-myc. Nature 312, 716–720 (1984). https://doi.org/10.1038/312716a0

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1038/312716a0

  • Springer Nature Limited

This article is cited by

Search

Navigation