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Chromosome translocation can occur on either side of the c-myc oncogene in Burkitt lymphoma cells

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Abstract

In Burkitt lymphoma cells reciprocal chromosomal translocations are observed between the long arm of chromosome 8 (8q24) and either the long arm of chromosome 14 (14q32), the short arm of chromosome 2 (2p12) or the long arm of chromo some 22 (22q11)1,2. Gene mapping studies have shown that c-myc, the cellular homologue of the viral myc oncogene, is localized at 8q24 (ref 3–5) and that the three immunoglobulin gene loci map at the breakpoints involved in the translocation: immunoglobulin heavy-chain genes are located at 14q32 (refs 6, 7), κ light chains at 2p12 (ref. 8) and λ light chains at, or close to, 22q11 (refs 9,10). This correlation suggests an association of immunoglobulin gene rearrangements with the occurrence of these specific translocations. By using in situ hybridization we have examined the translocation point with respect to c-myc in two cell tines containing 2;8 translocation, and report here that the c-myc gene remains on the chromosome 8 involved in the reciprocal exchange with chromosome 2. We have also confirmed that the c-myc gene moves from the translocated chromosome 8 in a cell line having a 8;14 translocation. These results show that chromosomal breakage can occur on either side of the c-myc gene in Burkitt lymphoma cells.

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References

  1. Manolov, G. & Manolova, Y. Nature 237, 33–34 (1974).

    Article  ADS  Google Scholar 

  2. Bernheim, A., Berger, R. & Lenoir, G. Cancer Genet. Cytogenet. 3, 307–315 (1981).

    Article  CAS  Google Scholar 

  3. Dalla-Favera, R. et al. Proc. natn. Acad. Sci. U.S.A. 79, 7824–7827 (1982).

    Article  ADS  CAS  Google Scholar 

  4. Neel, B. G., Jhanwar, S. C., Chaganti, R. S. K. & Hayward, W. S. Proc. natn. Acad. Sci. U.S.A. 79, 7842–7846 (1982).

    Article  ADS  CAS  Google Scholar 

  5. Taub, R. et al. Proc. natn. Acad. Sci. U.S.A. 79, 7837–7841 (1982).

    Article  ADS  CAS  Google Scholar 

  6. Croce, C. M. et al. Proc. natn. Acad. Sci. U.S.A. 76, 3416–3419 (1979).

    Article  ADS  CAS  Google Scholar 

  7. Hobart, M. J. et al. Ann. hum. Genet. 45, 331–335 (1981).

    Article  CAS  Google Scholar 

  8. Malcolm, S. et al. Proc. natn. Acad. Sci. U.S.A. 79, 4957–4961 (1982).

    Article  ADS  CAS  Google Scholar 

  9. Erikson, J., Martinis, J. & Croce, C. M. Nature 294, 173–175 (1981).

    Article  ADS  CAS  Google Scholar 

  10. de la Chappelle, A. et al. Nucleic Acids Res. 11, 1133–1144 (1983).

    Article  Google Scholar 

  11. Dalla-Favera, R., Martinotti, S., Gallo, R. C., Erikson, J. & Croce, C. M., Science 219, 963–967 (1983).

    Article  ADS  CAS  Google Scholar 

  12. Adams, J. M., Gerondakis, S., Webb, E., Corcoran, L. M. & Cory, S. Proc. natn. Acad. Sci. U.S.A. 80, 1982–1986 (1983).

    Article  ADS  CAS  Google Scholar 

  13. Hamlyn, P. H. & Rabbitts, T. H. Nature 304, 135–139 (1983).

    Article  ADS  CAS  Google Scholar 

  14. Battey, J. et al. Cell 34, 779–787 (1983).

    Article  CAS  Google Scholar 

  15. Erikson, J., Finan, J., Nowell, P. C. & Croce, C. M. Proc. natn. Acad. Sci. U.S.A. 79, 5611–5615 (1982).

    Article  ADS  CAS  Google Scholar 

  16. Davis, M., Malcolm, S., Hall, A. & Marshall, C. J. EMBO J. 2, 2281–2283 (1983).

    Article  CAS  Google Scholar 

  17. Croce, C. M. et al. Proc. natn. Acad. Sci. U.S.A. 80, 6922–6926 (1983).

    Article  ADS  CAS  Google Scholar 

  18. Rabbitts, T. H. Molec. Biol. Med 1, 275–281 (1983).

    CAS  PubMed  Google Scholar 

  19. Leder, P. et al. Science 222, 765–771 (1983).

    Article  ADS  CAS  Google Scholar 

  20. Erikson, J., Ar-Rushdi, A., Drivinga, H. L., Nowell, P. C. & Croce, C. M. Proc. natn. Acad. Sci. U.S.A. 80, 820–824 (1983).

    Article  ADS  CAS  Google Scholar 

  21. Maguire, R. T., Robins, T. S., Thorgeirsson, S. S. & Heilman, C. A. Proc. natn. Acad. Sci. U.S.A. 80, 1947–1950 (1983).

    Article  ADS  CAS  Google Scholar 

  22. Rabbitts, T. H., Forster, A., Baer, R. & Hamlyn, P. H. Nature 306, 806–809 (1983).

    Article  ADS  CAS  Google Scholar 

  23. Ar-Rushdi, A. et al. Science 222, 390–393 (1983).

    Article  ADS  CAS  Google Scholar 

  24. Westaway, D., Payne, G. & Varmus, H. E. Proc. natn. Acad. Sci. U.S.A. (in the press).

  25. Rabbitts, T. H., Hamlyn, P. H. & Baer, R. Nature 306, 760–765 (1983).

    Article  ADS  CAS  Google Scholar 

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Authors and Affiliations

  1. MRC Human Genetic Diseases Research Group, Biochemistry Department, Queen Elizabeth College, Campden Hill Road, London, W8 7AH, UK

    Mary Davis & Susan Malcolm

  2. MRC Laboratory of Molecular Biology, University Medical School, Hills Road, Cambridge, CB2 2QH, UK

    Terence H. Rabbitts

Authors
  1. Mary Davis
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  2. Susan Malcolm
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  3. Terence H. Rabbitts
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Davis, M., Malcolm, S. & Rabbitts, T. Chromosome translocation can occur on either side of the c-myc oncogene in Burkitt lymphoma cells. Nature 308, 286–288 (1984). https://doi.org/10.1038/308286a0

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