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The receptor for transepithelial transport of IgA and IgM contains multiple immunoglobulin-like domains

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Abstract

We have cloned and sequenced cDNA for the receptor that mediates the endocytosis and transcellular transport of IgA and IgM across many glandular epithelia into external secretions. This receptor contains five extracellular domains which are strikingly homologous to each other and to immunoglobulin variable regions.

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Authors and Affiliations

  1. Laboratory of Cell Biology, The Rockefeller University, New York, New York, 10021, USA

    Keith E. Mostov, Martin Friedlander & Günter Blobel

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  1. Keith E. Mostov
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  2. Martin Friedlander
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  3. Günter Blobel
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Mostov, K., Friedlander, M. & Blobel, G. The receptor for transepithelial transport of IgA and IgM contains multiple immunoglobulin-like domains. Nature 308, 37–43 (1984). https://doi.org/10.1038/308037a0

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