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Genetic and molecular mechanisms of viral pathogenesis: implications for prevention and treatment

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Abstract

The pathogenesis of infection of mice by the mammalian reoviruses involves several discrete steps. Each of the three viral outer capsid proteins has a highly distinct and specialized role: one protein (σ1) binds to cell surface receptors; a second protein (µ1C) determines the capacity for viral growth at mucosal surfaces; and the third protein (σ3) is responsible for inhibiting cell macromolecular synthesis. A detailed picture of the molecular basis of reovirus virulence and attenuation is now emerging.

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References

  1. Smith, H., Skehel, J. J. & Turner, M. J. (eds) The Molecular Basis of Microbial Pathogenicity, 1–355 (Verlag-Chemie, Basel, 1980).

  2. Mims, C. A. The Pathogenesis of Infectious Disease, 1–246 (Academic, London, 1976).

    Google Scholar 

  3. Fields, B. N. Archs Virol. 71, 95–107 (1982).

    Article  CAS  Google Scholar 

  4. Rott, R. Archs Virol. 59, 285–298 (1979).

    Article  CAS  Google Scholar 

  5. Joklik, W. K. Compreh. Virol. 2, 297–334 (1974).

    Google Scholar 

  6. Both, G. W., Lavi, S. & Shatkin, A. J. Cell 4, 173–180 (1975).

    Article  CAS  Google Scholar 

  7. Zweerink, H. J., McDowell, M. J. & Joklik, W. K. Virology 45, 716–723 (1971).

    Article  CAS  Google Scholar 

  8. Mustoe, T. A., Ramig, R. F., Sharpe, A. H. & Fields, B. N. Virology 89, 594–604 (1978).

    Article  CAS  Google Scholar 

  9. McCrae, M. & Joklik, W. K. Virology 89, 578–593 (1978).

    Article  CAS  Google Scholar 

  10. Hayes, E. C., Lee, P. W. K., Miller, S. E. & Joklik, W. K. Virology 108, 147–155 (1981).

    Article  CAS  Google Scholar 

  11. Rubin, D., Weiner, H. L., Fields, B. N. & Greene, M. I. J. Immun. 127, 1697–1701 (1981).

    CAS  PubMed  Google Scholar 

  12. Weiner, H. L., Ault, K. A. & Fields, B. N. J. Immun. 124, 2143–2148 (1980).

    CAS  PubMed  Google Scholar 

  13. Weiner, H. L. & Fields, B. N. J. exp. Med. 146, 1303–1310 (1977).

    Article  Google Scholar 

  14. Weiner, H. L., Greene, M. I. & Fields, B. N. J. Immun. 125, 278–282 (1980).

    CAS  PubMed  Google Scholar 

  15. Finberg, R., Weiner, H. L., Fields, B. N., Benacerraf, B. & Burakoff, S. J. Proc. natn. Acad. Sci. U.S.A. 76, 442–446 (1979).

    Article  ADS  CAS  Google Scholar 

  16. Weiner, H. L., Drayna, D., Averill, D. R. & Fields, B. N. Proc. natn. Acad. Sci. U.S.A. 74, 5744–5748 (1977).

    Article  ADS  CAS  Google Scholar 

  17. Ahmed, R. & Fields, B. N. Cell 28, 605–612 (1982).

    Article  CAS  Google Scholar 

  18. Sharpe, A. J. H. & Fields, B. N. Virology (in the press).

  19. Margolis, G., Kilham, L. & Gonatos, N. R. Lab. Invest. 24, 101–109 (1971).

    PubMed  Google Scholar 

  20. Raine, C. S. & Fields, B. N. J. Neuropath. exp. Neurol. 32, 19–33 (1973).

    Article  CAS  Google Scholar 

  21. Kilham, L. & Margolis, G. Lab. Invest. 21, 189–198 (1969).

    PubMed  Google Scholar 

  22. Weiner, H. L., Powers, M. L. & Fields, B. N. J. infect. Dis. 141, 609–616 (1980).

    Article  CAS  Google Scholar 

  23. Burstin, S., Spriggs, D. & Fields, B. N. Virology 117, 146–155 (1982).

    Article  CAS  Google Scholar 

  24. Spriggs, D. & Fields, B. N. Nature 297, 68–70 (1982).

    Article  ADS  CAS  Google Scholar 

  25. Finberg, R., Spriggs, D. S. & Fields, B. N. J. Immun. (in the press).

  26. Nepom, J. T. et al. J. exp. Med. 155, 155–167 (1982).

    Article  CAS  Google Scholar 

  27. Nepom, J. T. et al. Survey in Immunologic Research 11, 255–261 (1982).

    Google Scholar 

  28. Rubin, D. & Fields, B. N. J. exp. Med. 152, 853–868 (1980).

    Article  CAS  Google Scholar 

  29. Hrdy, D. B., Rubin, D. H. & Fields, B. N. Proc. natn. Acad. Sci. U.S.A. 79, 1298–1302 (1982).

    Article  ADS  CAS  Google Scholar 

  30. Plotkin, S. A., Farquhar, J., Katz, M. & Ingalls, T. H. Am. J. Epidem. 86, 468–477 (1967).

    Article  CAS  Google Scholar 

  31. Sabin, A. B. & Boulger, L. R. J. biol. Stand. 1, 115–118 (1973).

    Article  Google Scholar 

  32. Schwartz, A. J. E. Annals paediat. 202, 251–262 (1964).

    Google Scholar 

  33. Ahmed, R., Chakraborty, P. R. & Fields, B. N. J. Virol. 34, 285–287 (1980).

    CAS  PubMed  PubMed Central  Google Scholar 

  34. Mustoe, T. A., Ramig, R. F., Sharpe, A. H. & Fields, B. N. Virology 85, 545–556 (1978).

    Article  CAS  Google Scholar 

  35. Holland, J. J. et al. Compreh. Virol. 16, 137–192 (1980).

    Article  CAS  Google Scholar 

  36. Ahmed, R. & Graham, A. F. J. Virol. 23, 250–262 (1977).

    CAS  PubMed  PubMed Central  Google Scholar 

  37. Nonoyama, J., Watanabe, Y. & Graham, A. J. Virol. 6, 226–236 (1970).

    CAS  PubMed  PubMed Central  Google Scholar 

  38. Schuerch, A. R., Matshuhisha, I. & Joklik, W. K. Intervirology 3, 36–46 (1974).

    Article  CAS  Google Scholar 

  39. Ahmed, R. & Fields, B. N. Virology 111, 351–363 (1981).

    Article  CAS  Google Scholar 

  40. Holland, J. J. & Levine, A. Cell 14, 447–452 (1978).

    Article  Google Scholar 

  41. Fields, B. N. New Engl. J. Med. 287, 1026–1033 (1972).

    Article  CAS  Google Scholar 

  42. Fields, B. N. Curr. Topics Microbiol. Immun. 91, 1–24 (1981).

    CAS  Google Scholar 

  43. Del Canto, M. C., Rabinowitz, S. G. & Johnson, T. C. Br. J. exp. Med. Path. 57, 321–335 (1976).

    Google Scholar 

  44. Kilbourne, E. D. Prog. med. Virol. 5, 79–126 (1963).

    CAS  Google Scholar 

  45. Mayer, U., Schulman, J. L. & Kilbourne, E. D. J. Virol. 11, 272–278 (1973).

    CAS  PubMed  PubMed Central  Google Scholar 

  46. Boulanger, P. & Lonberg-Holm, K. in Virus Receptors Pt 2 (eds Lonberg-Holm, K. & Philipson, L.) 21–46 (Chapman & Hall, New York, 1981).

    Book  Google Scholar 

  47. Philipson, L., Beatrice, S. T. & Crowell, R. L. Virology 54, 69–79 (1973).

    Article  CAS  Google Scholar 

  48. Norrby, E., Marusyk, H. & Hammerskjold, M. L. Virology 36, 477–489 (1969).

    Article  Google Scholar 

  49. Scheid, A. in Viral Receptors Pt 2 (eds Lonberg-Holm, K. & Philipson, L.) 47–62 (Chapman & Hall, New York, 1981).

    Book  Google Scholar 

  50. Wiley, D. C., Wilson, I. A. & Skehel, J. J. Nature 289, 373–378 (1981).

    Article  ADS  CAS  Google Scholar 

  51. Bucher, D. & Palese, P. in The Influenza Viruses and Influenza (ed. Kilbourne, E.) 83–119 (Academic, New York, 1975).

    Google Scholar 

  52. Hosaka, V. & Shimiza, K. in Virus Infection and the Cell Surface (eds Poste, G. & Nicholson, G.) 129–156 (North-Holland, Amsterdam, 1977).

    Google Scholar 

  53. Liu, Y. N., Bona, C. A. & Schulman, J. L. J. exp. Med. 154, 1525–1538 (1981).

    Article  CAS  Google Scholar 

  54. Sacks, D. L., Esser, K. M. & Sher, A. J. exp. Med. 155, 1108–1119 (1982).

    Article  CAS  Google Scholar 

  55. Potocnjak, P., Zavala, F., Nussenzweig, R. & Nussenzweig, V. Science 215, 1637–1639 (1982).

    Article  ADS  CAS  Google Scholar 

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Authors and Affiliations

  1. Departments of Microbiology and Pathology, Harvard Medical School,

    Bernard N. Fields & Mark I. Greene

  2. Department of Medicine (Infectious Disease), Brigham and Women's Hospital, Boston, Massachusetts, 02115, USA

    Bernard N. Fields & Mark I. Greene

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  1. Bernard N. Fields
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  2. Mark I. Greene
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Fields, B., Greene, M. Genetic and molecular mechanisms of viral pathogenesis: implications for prevention and treatment. Nature 300, 19–23 (1982). https://doi.org/10.1038/300019a0

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