Abstract
The immune response (I) region of the major histocompatibility complex encodes a set of cell-surface glycoproteins, the Ia antigens, which are probably identical with the products of immune response genes. Chemically, the polymorphic Ia antigens controlled by the I–A and I–E subregions consist of two associated polypeptide chains,α and β (ref. 1). In addition, this α–β complex is noncovalently associated with another chain of 31,000 molecular weight which, because of its non-polymorphic nature, has been designated invariant (Ii) chain2. Whereas Ia antigens are known to span the plasma membrane3, the Ii chain has been found in the cytoplasm but not on the surface of lymphocytes2. Here we describe a monoclonal antibody detecting free Ii chains on the cell surface which are not associated with Ia antigens.
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Koch, N., Koch, S. & Hämmerling, G. Ia invariant chain detected on lymphocyte surfaces by monoclonal antibody. Nature 299, 644–645 (1982). https://doi.org/10.1038/299644a0
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DOI: https://doi.org/10.1038/299644a0
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