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Serotonin and cyclic AMP close single K+ channels in Aplysia sensory neurones

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Abstract

We have identified a serotonin-sensitive K+ channel with novel properties. The channel is active at the resting potential; its gating is moderately affected by membrane potential and is not dependent on the activity of intracellular calcium ions. Application of serotonin to the cell body or intracellular injection of cyclic AMP causes prolonged and complete closure of the channel, thereby reducing the effective number of active channels in the membrane. The closure of the channel can account for the increases in the duration of the action potential, Ca2+ influx, and transmitter release which underlie behavioural sensitization, a simple form of learning.

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Authors and Affiliations

  1. Center for Neurobiology and Behavior, Departments of Pharmacology and Physiology, Columbia University, College of Physicians and Surgeons, and The New York State Psychiatric Institute, New York, New York, 10032, USA

    Steven A. Siegelbaum, Joseph S. Camardo & Eric R. Kandel

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  1. Steven A. Siegelbaum
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  2. Joseph S. Camardo
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  3. Eric R. Kandel
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Siegelbaum, S., Camardo, J. & Kandel, E. Serotonin and cyclic AMP close single K+ channels in Aplysia sensory neurones. Nature 299, 413–417 (1982). https://doi.org/10.1038/299413a0

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