Skip to main content
SpringerLink
Log in

Bradykinin receptor-mediated chloride secretion in intestinal function

  • Letter
  • Published:

From Nature

View current issue Submit your manuscript

Abstract

The nonapeptide bradykinin (Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg) and the decapeptide kallidin (Lys-bradykinin) are released during tissue damage and cause vasodilation, increased vascular permeability, altered gut motility and pain1–4. Accordingly, they have been implicated in several pathological processes, including carcinoid tumours and postgastrectomy dumping syndrome. Symptoms of these two syndromes include flushing, light-headedness, headaches and diarrhoea5–9. Increased blood levels of bradykinin5,7–9 and kallikrein9, the bradykinin-releasing enzyme, have been noted in such patients and may explain these symptoms. However, while kinin-forming and -destroying activity has been noted in the gut10–14, bradykinin itself has not been directly demonstrated. Moreover, while bradykinin influences gut motility and electrical activity15,25,26, most clinical diarrhoea is due to ion and fluid secretion into the gut lumen rather than altered motility16. We describe here specific bradykinin receptors in intestinal mucosa and muscle. We also report that bradykinin and several peptide analogues potently stimulate chloride secretion in the gut with a peptide specificity indicative of specific receptor interactions. These findings suggest a physiological and a pathological role for kinins in intestinal function. Throughout this report the term kinin will indicate both bradykinin and kallidin activities since in several cases the true active form is unknown.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Rocha Y, Silva, M. & Rosenthal, S. R. J. Pharmac. exp. Ther. 132, 110–116 (1961).

    Google Scholar 

  2. Juan, H. & Lembeck, F. Naunyn-Schmiedebergs Archs Pharmak. 283, 151–164 (1974).

    Article  CAS  Google Scholar 

  3. Copley, A. L. & Tsulcua, V. Biochem. Pharmac. 10, 67–85 (1962).

    Article  CAS  Google Scholar 

  4. Regoli, D. & Barabe, J. Pharmac. Rev. 32, 1–45 (1980).

    CAS  Google Scholar 

  5. Oates, J. A., Pettinger, W. A. & Doctor, R. B. J. clin. Invest. 45, 173–178 (1966).

    Article  CAS  Google Scholar 

  6. Oates, J. A., Melmon, K., Sjoerdsma, A., Gillespie, L. & Mason, D. T. Lancet i, 514–517 (1964).

    Article  Google Scholar 

  7. Zeitlin, I. J. & Smith, A. N. Lancet ii, 986–991 (1966).

    Article  Google Scholar 

  8. Cuschieri, A. & Onabanjo, D. A. Br. med. J. 3, 565–566 (1971).

    Article  CAS  Google Scholar 

  9. Wong, P. Y., Talamo, R. C., Babior, B. M., Raymond, G. G. & Colman, R. W. Annls int. Med. 80, 577–581 (1974).

    Article  CAS  Google Scholar 

  10. Amundsen, E. & Nustad, K. J. Physiol., Lond. 179, 479–488 (1965).

    Article  CAS  Google Scholar 

  11. Fasth, S., Hulten, L., Johnson, B. J., Nordgren, S. & Zeitlin, I. J. J. Physiol., Lond. 285, 471–478 (1978).

    Article  CAS  Google Scholar 

  12. Zeitlin, I. J. in Bradykinin and Related Kinins: Cardiovascular, Biochemical and Neural Actions (eds Sicuteri, F., Rocha Y Silva, M. & Bock, N.) 329–339 (Plenum, New York, 1970).

    Book  Google Scholar 

  13. Zeitlin, I. J. Br. J. Pharmac. 42, 648–649 (1972).

    Google Scholar 

  14. Zeitlin, I. J. & Smith, N. Gut 14, 133–138 (1973).

    Article  CAS  Google Scholar 

  15. Hardcastle, J., Hardcastle, P. T., Flower, R. J. & Sanford, P. A. Experientia 34, 617–618 (1978).

    Article  CAS  Google Scholar 

  16. Sodeman, N. A. & Watson, D. W. in Pathologic Physiology: Mechanisms of Disease (eds Sodeman, W. A. & Sodeman, W. A.) 767–789 (W. B. Saunders, Philadelphia, 1974).

    Google Scholar 

  17. Innis, R. B., Manning, D. C., Stewart, J. M. & Snyder, S. H. Proc. natn. Acad. Sci. U.S.A. 78, 2630–2634 (1981).

    Article  ADS  CAS  Google Scholar 

  18. Field, M., Fromm, D. & McColl, I. Am. J. Physiol. 220, 1388–1396 (1971).

    CAS  PubMed  Google Scholar 

  19. Schwartz, C. J., Kimberg, D. V., Sheerin, H. E., Field, M. & Said, S. I. J. clin. Invest. 54, 536–544 (1974).

    Article  CAS  Google Scholar 

  20. Kachur, J. F., Miller, R. J., Field, M. & Rivier, J. J. Pharmac. exp. Ther. 220, 456–463 (1982).

    CAS  Google Scholar 

  21. Kachur, J. F., Miller, R. J., Field, M. & Rivier, J. J. Pharmac. exp. Ther. 220, 449–455 (1982).

    CAS  Google Scholar 

  22. Bolton, J. & Field, M. J. Membrane Biol. 35, 159–174 (1977).

    Article  CAS  Google Scholar 

  23. Musch, M., Kachur, J., Miller, R., Stoff, J. & Field, M. Gastroenterology 82, 1257 (1982).

    Google Scholar 

  24. Cuthbert, A. W. & Margolius, H. S. J. Physiol., Lond. 319, 45 (1981).

    Google Scholar 

  25. Cuthbert, A. W. & Margolius, H. S. Br. J. Pharmac. 75, 587–598 (1982).

    Article  CAS  Google Scholar 

  26. Moriwaki, C., Fujimori, H., Moriya, H. & Kizuki, K. Chem. Pharmac. Bull. 25, 1174–1178 (1977).

    Article  CAS  Google Scholar 

  27. Moriwaki, C. & Fujimor, H. Chem. Pharmac. Bull. 29, 804–809 (1981).

    Article  CAS  Google Scholar 

  28. Donowitz, M., Charney, A. N. & Tai, Y. H. in Mechanisms of Intestinal Secretion (ed. Binder, H.) 217–230 (Liss, New York, 1979).

    Google Scholar 

  29. Lewis, G. P. in Bradykinin, Kallidin and Kallikrein (ed. Erdos, E. G.) 516–530 (Springer, New York, 1970).

    Book  Google Scholar 

  30. Silverstin, E., Fierst, S. M., Simon, M. R., Weinstock, J. V. & Friedland, J. Am. J. clin. Path. 75, 175–178 (1981).

    Article  Google Scholar 

  31. Weaver, L. J., Simonowitz, D., Driscoll, R. & Solliday, N. J. surg. Res. 29, 475–478 (1980).

    Article  CAS  Google Scholar 

  32. Brown, D. J. C., Khan, J. A., Copeland, G. & Jewell, D. P. J. clin. Lab. Immun. 4, 53–57 (1980).

    CAS  Google Scholar 

  33. Young, W. S. & Kuhar, M. J. Brain Res. 179, 255–270 (1979).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Departments of Neuroscience, Pharmacology and Experimental Therapeutics, Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, 725 North Wolfe Street, Baltimore, Maryland, 21205, USA

    Donald C. Manning & Solomon H. Snyder

  2. Departments of Pharmacological and Physiological Sciences and Medicine, University of Chicago, Chicago, Illinois, 60637, USA

    James F. Kachur, Richard J. Miller & Michael Field

Authors
  1. Donald C. Manning
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Solomon H. Snyder
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. James F. Kachur
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Richard J. Miller
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Michael Field
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Manning, D., Snyder, S., Kachur, J. et al. Bradykinin receptor-mediated chloride secretion in intestinal function. Nature 299, 256–259 (1982). https://doi.org/10.1038/299256a0

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1038/299256a0

  • Springer Nature Limited

This article is cited by

Search

Navigation