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Structural analysis of the prolactin gene suggests a separate origin for its 5′ end

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Abstract

Prolactin, growth hormone (GH) and placental lactogen constitute a family of polypeptide hormones which share certain structural1–7 and functional8 features. The prolactin and GH genes evolved from a gene duplication about 400 million years ago9 and, in humans, segregated onto chromosomes 6 and 17 respectively10,11. We expand here previous reports12,13 on the general organization of the rat prolactin gene, rPRL, assign its haploid gene number and extend its DNA sequence analysis. We postulate that a direct repeat flanking exon I may be the remnant of an insertional event.

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Author notes

  1. Nancy E. Cooke

    Present address: Endocrine Section, Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, 19104, USA

Authors and Affiliations

  1. Howard Hughes Medical Institute Laboratory, Department of Medicine, Biochemistry and Biophysics,

    Nancy E. Cooke & John D. Baxter

  2. Metabolic Research Unit, University of California, San Francisco, California, 94143, USA

    Nancy E. Cooke & John D. Baxter

Authors
  1. Nancy E. Cooke
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  2. John D. Baxter
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Cooke, N., Baxter, J. Structural analysis of the prolactin gene suggests a separate origin for its 5′ end. Nature 297, 603–606 (1982). https://doi.org/10.1038/297603a0

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  • DOI: https://doi.org/10.1038/297603a0

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