Abstract
The Ia antigens of the mouse are the basis for the genetic control of the immune response. The HLA-D/DR locus is considered to be the human counterpart of the Ia subregion of the murine major histocompatibility complex1–4. The HLA-D/DR antigens are polymorphic, and eight well defined alleles have been identified using alloantisera5. More recently, ‘supertypic’ antigens (MB and MT) have been defined which identify clusters of HLA-D/DR specificities6–9. Little is known about the molecular basis for the cellular and serological polymorphism of the HLA-D/DR antigens, as alloantisera are usually of very low titre and heteroantisera frequently lack monospecificity. We present here the preparation and characterization of a monoclonal antibody which defines a new polymorphic system of the HLA-D/DR region. This and similar antisera should now begin to provide the reagents with which to correlate molecular structure with the functional repertoire of the human Ia-like antigens.
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Nadler, L., Stashenko, P., Hardy, R. et al. Monoclonal antibody identifies a new Ia-like (p29,34) polymorphic system linked to the HLA-D/DR region. Nature 290, 591–593 (1981). https://doi.org/10.1038/290591a0
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DOI: https://doi.org/10.1038/290591a0
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