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Interferon-neutralizing antibodies in a patient treated with human fibroblast interferon

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Abstract

During recent years clinical trials have shown that human leukocyte Interferon (HuIFN-α) may be useful in the treatment of cancer, but very little has been done concerning the possible use of human fibroblast Interferon (HuIFN-β). Treuner et al.1 recently reported the successful treatment of a nasopharyngeal carcinoma with HuIFN-β: in the course of IFN-therapy a HuIFN-β neutralizing activity appeared in the serum of this patient. We report here that such activity is due to IgG antibodies—this study is the first to present evidence for antigenicity of IFN in a homologous system.

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Authors and Affiliations

  1. Department for Medical Virology and Epidemiology of Virus Diseases, Hygiene Institute, University of Tübingen, D-7400, Tübingen, 1, FRG

    Angelika Vallbracht & B. Flehmig

  2. Division of Hematology, Department of Pediatrics, University of Tübingen, D-7400, Tübingen, 1, FRG

    J. Treuner & D. Niethammer

  3. Dr Rentschler & Co., Laupheim, FRG

    K.-E. Joester

Authors
  1. Angelika Vallbracht
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  2. J. Treuner
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  3. B. Flehmig
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  4. K.-E. Joester
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  5. D. Niethammer
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Vallbracht, A., Treuner, J., Flehmig, B. et al. Interferon-neutralizing antibodies in a patient treated with human fibroblast interferon. Nature 289, 496–497 (1981). https://doi.org/10.1038/289496a0

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  • DOI: https://doi.org/10.1038/289496a0

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