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The structure of histone H1 and its location in chromatin

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Abstract

On the basis of their primary structure, the lysine-rich histones are a unified family of proteins. Each has an amino acid chain which falls into three distinct domains. Only the central domain (∼80 residues) is in a folded conformation. It is protected from trypsin digestion in chromatin and corresponds to the segment of highest sequence conservation. Without the flanking domains it is able to close two full turns of DNA in the nucleosome and can thus locate the H1 molecule.

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Authors and Affiliations

  1. Biophysics Laboratories, King's College, London, WC2B 5RL, UK

    J. Allan

  2. Biophysics Laboratories, Portsmouth Polytechnic, Portsmouth, PO1 2QQ, UK

    P. G. Hartman & C. Crane-Robinson

  3. Department of Biochemistry, Autonomous University, Barcelona, Spain

    F. X. Aviles

Authors
  1. J. Allan
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  2. P. G. Hartman
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  3. C. Crane-Robinson
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  4. F. X. Aviles
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Allan, J., Hartman, P., Crane-Robinson, C. et al. The structure of histone H1 and its location in chromatin. Nature 288, 675–679 (1980). https://doi.org/10.1038/288675a0

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  • DOI: https://doi.org/10.1038/288675a0

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