Abstract
The enkephalins Met-enkephalin and Leu-enkephalin were first isolated from porcine brain by Hughes and co-workers1. We have recently isolated from bovine adrenals another enkephalin with the structure Tyr-Gly-Gly-Phe-Met-Arg-Phe, or Met-enkephalin-Arg6-Phe7 (ref. 2). We report here that this new heptapeptide is found in human, rat and bovine striatum in concentrations comparable with or greater than that of Leu-enkephalin. This molecule should not be considered as a mere precursor of Met-enkephalin. A pharmacological study indicates that this naturally occurring enkephalin has similar properties to the two enkephalins characterized earlier.
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References
Hughes, J. et al. Nature 258, 577–579 (1975).
Stern, A. S. et al. Proc. natn. Acad. Sci. U.S.A. 76, 6680–6683 (1979).
Simantov, R. & Snyder, S. H. Proc. natn. Acad. Sci. U.S.A. 73, 2515–2519 (1976).
Rossier, J., Vargo, T., Minick, S., Ling, N., Bloom, F. E. & Guillemin, R. Proc. natn. Acad. Sci. U.S.A. 74, 5162–5165 (1977).
Gerber, L. D., Stein, S., Rubinstein, M., Wideman, J. & Udenfriend, S. Brain Res. 151, 117–126 (1978).
Huang, W. Y., Chang, R. C., Kastin, A. J., Coy, D. H. & Schally, A. V. Proc. natn. Acad. Sci. U.S.A. 76, 6177–6180 (1979).
Inturessi, C. E. et al. Proc. natn. Acad. Sci. U.S.A. 77 (in the press).
Lord, J. A., Waterfield, A. A., Hughes, J. & Kosterlitz, H. W. Nature 267, 495–499 (1977).
Kosterlitz, H. W., Lord, J. A. H., Paterson, S. J. & Waterfield, A. A. Br. J. Pharmac. 68, 333–342 (1980).
Livett, B. G., Kozousek, V., Mizobe, F. & Dean, D. M. Nature 278, 256–257 (1979).
Rossier, J., Bayon, A., Vargo, T., Ling, N., Guillemin, R. & Bloom, F. Life Sci. 21, 847–852 (1977).
Kimura, S., Lewis, R. V., Stern, A. S., Rossier, J., Stein, S. & Udenfriend, S. Proc. natn. Acad. Sci. U.S.A. 77, 1681–1685 (1980).
Audigier, Y., Mazarguil, H., Gout, R. & Cros, J. Eur. J. Pharmac. 63, 35–46 (1980).
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Rossier, J., Audigier, Y., Ling, N. et al. Met-enkephalin-Arg6-Phe7, present in high amounts in brain of rat, cattle and man, is an opioid agonist. Nature 288, 88–90 (1980). https://doi.org/10.1038/288088a0
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DOI: https://doi.org/10.1038/288088a0
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