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Depolarisation-induced changes in muscarinic cholinergic receptors in synaptosomes

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Abstract

PROLONGED exposure of receptors to ligands can result in a reduction in the number of available binding sites1–8. This constitutes one possible homeostatic mechanism in the control of interneural communication as there is a functional desensitisation of target tissues. The association between transmission-linked events and the extent of ligand binding can be investigated conveniently in synaptosome preparations. Here we present evidence for what may be a similar desensitisation phenomenon for pre- or postsynaptic muscarinic acetylcholine receptors on synaptosomal membranes as a result of depolarisation mediated via prolonged or persistent opening of sodium channels.

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Authors and Affiliations

  1. Department of Biochemistry, Imperial College, London, SW7

    Y. A. LUQMANI & H. F. BRADFORD

  2. Division of Molecular Pharmacology, National Institute for Medical Research, Mill Hill, London, NW7, UK

    N. J. M. BIRDSALL & E. C. HULME

Authors
  1. Y. A. LUQMANI
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  2. H. F. BRADFORD
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  3. N. J. M. BIRDSALL
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  4. E. C. HULME
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LUQMANI, Y., BRADFORD, H., BIRDSALL, N. et al. Depolarisation-induced changes in muscarinic cholinergic receptors in synaptosomes. Nature 277, 481–483 (1979). https://doi.org/10.1038/277481a0

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  • DOI: https://doi.org/10.1038/277481a0

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