Skip to main content
SpringerLink
Log in

X-ray dose fractionation and oncogenic transformations in cultured mouse embryo cells

  • Letter
  • Published:

From Nature

View current issue Submit your manuscript

Abstract

THE effect of dose fractionation on oncogenic transformation can be studied quantitatively by using recently developed cell lines in which transformation is scored by the loss of contact inhibition1,2. We report here that splitting the dose into two fractions enhances oncogenic transformation at low doses, whereas at high doses fractionation results in less effect than the same total dose in a single exposure. This observation is pertinent to the calculation of cancer risk estimates for multiple low-dose exposures, to which radiation workers or members of the general public are exposed, by means of a linear extrapolation from observed human data at high dose levels.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Reznikoff, C. A., Brankow, D. W. & Heidelberger, C. Cancer Res. 33, 3231–3238 (1973).

    PubMed  CAS  Google Scholar 

  2. Reznikoff, C. A., Brankow, D. W. & Heidelberger, C. Cancer Res. 33, 3239–3249 (1973).

    PubMed  CAS  Google Scholar 

  3. Terzaghi, M. & Little, J. B. Int. J. Radiat. Biol. 29, 583–587 (1976).

    CAS  Google Scholar 

  4. Borek, C. & Hall, E. J. Nature 252, 499–501 (1974).

    Article  ADS  CAS  PubMed  Google Scholar 

  5. Elkind, M. M., Sutton-Gilbert, H., Moses, W. B., Alescio, T. & Swain, R. W. Radiat. Res. 25, 359–376 (1965).

    Article  ADS  CAS  PubMed  Google Scholar 

  6. Belli, J. A., Discus, G. J. & Bonte, F. J. J. natn. Cancer Inst. 38, 673–682 (1967).

    CAS  Google Scholar 

  7. Kaplan, H. S. & Brown, M. B. J. natn. Cancer Inst. 13, 185 (1952).

    CAS  Google Scholar 

  8. Kaplan, H. S. & Brown, M. B. The Leukemias: Etiology, Pathophysiology and Treatment (eds. Rebuck, J. W., Bethell, F. H. & Monto, R. W.) 163 (Academic, New York, 1957).

    Book  Google Scholar 

  9. Metalli, P., Silini, G., Castillo, S. & Covelli, V. Radiation Induced Cancer, IAEA-SM-118/14, 277 (International Atomic Energy Agency, (1969).

    Google Scholar 

  10. Upton, A. C., Jenkins, V. K. & Conklin, J. W. A. N.Y. Acad. Sci. 114, 189 (1964).

    Article  ADS  CAS  Google Scholar 

  11. Report on the Advisory Committee on the Biological Effects of Ionizing Radiations (BEIR) (National Academy of Sciences, National Research Council, Washington DC, 1972).

Download references

Author information

Authors and Affiliations

  1. Radiological Research Laboratory, College of Physicians and Surgeons, Columbia University, New York, New York, 10032

    RICHARD MILLER & ERIC J. HALL

Authors
  1. RICHARD MILLER
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. ERIC J. HALL
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

MILLER, R., HALL, E. X-ray dose fractionation and oncogenic transformations in cultured mouse embryo cells. Nature 272, 58–60 (1978). https://doi.org/10.1038/272058a0

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1038/272058a0

  • Springer Nature Limited

This article is cited by

Search

Navigation