Skip to main content
SpringerLink
Log in

A novel continuous sequence of 41 aspartic and glutamic residues in a non-histone chromosomal protein

  • Letter
  • Published:

From Nature

View current issue Submit your manuscript

Abstract

THE structural functions of four of the five histones are now partially understood1 and the nucleosome structure of chromatin well established2–4. However, superimposed on this basic nucleosome structure is some heterogeneity with respect to the other chromosomal proteins, since although it has been shown that isolated nucleosomes contain non-histone chromosomal proteins5,6, there are insufficient of some classes for one per nucleosome. These nucleosomal non-histone chromosomal proteins have been designated the high-mobility group (HMG) proteins. They have been fractionated, and the main components, HMG 1, HMG 2, HMG 14 and HMG 17 have been isolated in a pure form7–9. The complete amino acid sequence of one of these proteins, HMG 17, has been determined10. We report here that the C-terminal region of protein HMG 1 contains an extremely unusual sequence of amino acids—41 aspartic and glutamic acid residues.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Bradbury, E. M. in The Organization and Expression of the Eukaryotic Genome 99–124 (Academic, New York, 1977).

    Google Scholar 

  2. Thomas, J. O. in The Organization and Expression of the Eukaryotic Genome 83–98 (Academic, New York, 1977).

    Google Scholar 

  3. Kornberg, R. D. Science 184, 868–871 (1974).

    Article  ADS  CAS  Google Scholar 

  4. Finch, J. T. et al. Nature 269 29–36 (1977).

    Article  ADS  CAS  Google Scholar 

  5. Goodwin, G. H., Woodhead, L. & Johns, E. W. FEBS Lett. 73, 85–88 (1977).

    Article  CAS  Google Scholar 

  6. Bakayev, V. V., Bakayeva, T. G. & Varshavsky, A. J. Cell 11, 619–629 (1977).

    Article  CAS  Google Scholar 

  7. Goodwin, G. H., Nicolas, R. H. & Johns, E. W. Biochim. biophys. Acta 405, 280–291 (1975).

    Article  CAS  Google Scholar 

  8. Goodwin, G. H., Rabbani, A., Nicolas, R. H. & Johns, E. W. FEBS Lett. (in the press).

  9. Sanders, C. thesis, London Univ. (1975).

  10. Walker, J. M., Hastings, J. R. B. & Johns, E. W. Eur. J. Biochem. 76, 461–468 (1977).

    Article  CAS  Google Scholar 

  11. Walker, J. M., Shooter, K. V., Goodwin, G. H. & Johns, E. W. Biochem. biophys. Res. Commun. 70, 88–93 (1976).

    Article  CAS  Google Scholar 

  12. Walker, J. M., Goodwin, G. H. & Johns, E. W. Eur. J. Biochem. 62, 461–469 (1976).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Chester Beatty Research Institute, Institute of Cancer Research: Royal Cancer Hospital, Fulham Road, London, SW3, UK

    JOHN M. WALKER, JEREMY R. B. HASTINGS & ERNEST W. JOHNS

Authors
  1. JOHN M. WALKER
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. JEREMY R. B. HASTINGS
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. ERNEST W. JOHNS
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

WALKER, J., HASTINGS, J. & JOHNS, E. A novel continuous sequence of 41 aspartic and glutamic residues in a non-histone chromosomal protein. Nature 271, 281–282 (1978). https://doi.org/10.1038/271281a0

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/271281a0

  • Springer Nature Limited

This article is cited by

Search

Navigation