Abstract
IT is well known that Epstein–Barr virus (EBV) transforms human lymphocytes in vitro, and lymphoblastoid cell lines are established1. Macrophages enhance transformation by EBV in vitro2 but may not be essential3. Inhibition of transformation by EBV in vitro has also been reported, and was first observed when lymphocytes from an adult donor with antibody to EBV were infected with EBV and co-cultivated with autochthonous fibroblasts derived from skin4. Fibroblasts of foetal origin did not have this inhibitory effect. Further studies established the principle that co-cultivation of EBV-infected lymphocytes with autochthonous or allogeneic fibroblasts of adult but not foetal origin, was associated with inhibition of transformation by EBV (ref. 5). This report presents evidence that this type of inhibition of transformation by EBV is specifically mediated by mononuclear cell preparations from donors previously infected with EBV. An immunological basis is highly probable.
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Moss, D., SCOTT, W. & POPE, J. An immunological basis for inhibition of transformation of human lymphocytes by EB virus. Nature 268, 735–736 (1977). https://doi.org/10.1038/268735a0
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DOI: https://doi.org/10.1038/268735a0
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