Abstract
BOTH basophilic granulocytes and tissue mast cells are known to have receptors for immunoglobulin E (IgE) and granules which contain histamine and heparin1,2. In spite of their similar physiological role, these two types of cells are thought to be independent cell lineages; the former are derived from the bone marrow, and the latter are connective tissue cells2. The differentiation of mast cells from their precursors, which were supposed to be undifferentiated mesenchymal cells, and the proliferation of these precursors were reported to occur in the skin of mice3,4. These results do not necessarily exclude the possibility that the precursor cells themselves are originated from the bone marrow, however. To examine such a possibility, we investigated whether mast cells of the donor origin appeared in radiation chimaeras, using the giant granules of beige (Chediak–Higashi syndrome) mouse5 as a quantitative marker for mast cells. We have found that tissue mast cells can be derived from grafted bone marrow cells in irradiated mice.
Similar content being viewed by others
References
Ishizaka, K. & Ishizaka, T. Archs Path. Lab. Med. 100, 289–292 (1976).
Block, M. T. in Text-Atlas of Hematology, 39–40 (Lea and Febiger, Philadelphia, 1976).
Walker, B. E. Nature 192, 980–981 (1961).
Takeoka, O., Ashihara, T. & Tada, N. Acta Path. Jap. 26, 693–702 (1976).
Chi, E. Y. & Lagunoff, D. J. Histochem. Cytochem. 23, 117–122 (1975).
Sheehan, H. L. & Storey, G. W. J. Path. Bact. 59, 336–337 (1947).
Murphy, E. D., Harrison, D. E. & Roths, J. B. Transplantation 15, 526–530 (1973).
Enerbäck, L. Acta Path. Microbiol. Scand. 66, 289–302 (1966).
Ruitenberg, E. J. & Elgersma, A. Nature 264, 258–260 (1976).
Vicklicky, V., Sima, P. & Pritchard, H. Folia Biol. (Praha) 19, 247–251 (1973).
Keller, R., Hess, M. W. & Riley, J. F. Experientia 32, 171–172 (1976).
Kitamura, Y., Kawata, T., Suda, O. & Ezumi, K. Transplantation 10, 455–462 (1970).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
KITAMURA, Y., SHIMADA, M., HATANAKA, K. et al. Development of mast cells from grafted bone marrow cells in irradiated mice. Nature 268, 442–443 (1977). https://doi.org/10.1038/268442a0
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1038/268442a0
- Springer Nature Limited
This article is cited by
-
New perspectives on the origins and heterogeneity of mast cells
Nature Reviews Immunology (2023)
-
Trained immunity in type 2 immune responses
Mucosal Immunology (2022)
-
Mast Cell Biology at Molecular Level: a Comprehensive Review
Clinical Reviews in Allergy & Immunology (2020)
-
Apoptotic resistance of human skin mast cells is mediated by Mcl-1
Cell Death Discovery (2017)
-
CCR2− and CCR2+ corneal macrophages exhibit distinct characteristics and balance inflammatory responses after epithelial abrasion
Mucosal Immunology (2017)