Abstract
GENE products of the major histocompatibility complex (H–2 in the mouse) regulate cellular interactions between various immunocompetent cell types1–4 as well as interactions between thymus-dependent (T) killer cells and chemically altered or virus-infected target cells5,6. Identity of certain determinants of H–2 seems to be necessary for effective interaction between any two participating cell types. We have investigated the H–2 compatibility requirement for the suppressive interaction between T suppressor cells and mitogen-responsive cells in cultures infected with Friend leukaemia virus and find that there is an H–2D compatibiilty requirement. However, the H–2 restriction we observe is mediated by a third cell type which we term an ‘interfering cell’. The two principal cell types, that is, T suppressor cells and mitogen-responsive cells, can interact even if they do not share any H–2 determinants provided that the interfering cells are functionally absent. This may provide an alternative explanation for the role the major histocompatibility complex in regulating other immune cellular interactions.
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KUMAR, V., BENNETT, M. H–2 compatibility requirements for T suppressor cell functions induced by Friend leukaemia virus. Nature 265, 345–347 (1977). https://doi.org/10.1038/265345a0
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DOI: https://doi.org/10.1038/265345a0
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