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Lesions of ascending dopaminergic pathways decrease forebrain glucose uptake

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Abstract

WE describe the changes in forebrain glucose uptake following various lesions of ascending catecholaminergic pathways. These pathways include dopaminergic fibres arising from the pars compacta of the substantia nigra (A9 of Dahlström and Fuxe1) and from other cell bodies in the ventral tegmentum (A8, A10) and noradrenergic fibres originating from the locus coeruleus (A6) and from other cell bodies in the midbrain (A7) and medulla (A1, A2, A5)2. We have found that destruction of dopaminergic fibres results in decreased forebrain glucose uptake.

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Authors and Affiliations

  1. Laboratory of Neurophysiology, National Institute of Mental Health, Bethesda, Maryland, 20014

    WILLIAM J. SCHWARTZ, FRANK R. SHARP, RUFUS H. GUNN & EDWARD V. EVARTS

Authors
  1. WILLIAM J. SCHWARTZ
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  2. FRANK R. SHARP
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  3. RUFUS H. GUNN
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  4. EDWARD V. EVARTS
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SCHWARTZ, W., SHARP, F., GUNN, R. et al. Lesions of ascending dopaminergic pathways decrease forebrain glucose uptake. Nature 261, 155–157 (1976). https://doi.org/10.1038/261155a0

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  • DOI: https://doi.org/10.1038/261155a0

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