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Polymorphism of a synthetic DNA in solution

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Abstract

EARLY work on the X-ray diffraction of DNA fibres showed that DNA can adopt different conformations, and up to now at least four different double-helical models have been described in detail: the A, B, C, and D forms1–4. During recent years, it has become likely that DNA in solution also occurs in different conformations5–7. For studying such helix–helix transitions synthetic polynucleotides with a defined sequence offer an important tool, since in natural DNA only a very small fraction of the molecule usually has a particular sequence and, sequence-specific effects of the conformation will therefore escape detection.

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  1. Fachbereich Biologie, Universitat Konstanz, D-7750, Konstanz, West Germany

    FRITZ M. POHL

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  1. FRITZ M. POHL
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POHL, F. Polymorphism of a synthetic DNA in solution. Nature 260, 365–366 (1976). https://doi.org/10.1038/260365a0

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