Abstract
CLONIDINE and some other antihypertensive drugs exert their effect by acting on the central nervous system1–4. Some α-adrenoceptor blocking drugs antagonise the centrally mediated hypotensive effect of clonidine5–7. It has therefore been suggested that clonidine acts by stimulating central α-adrenoceptors, bringing about a depression of the cardiovascular system. The involvement of classical α-adreno-ceptors has, however, been challenged8,9. Moreover, in the brain tissue clonidine may even be a potent α-adrenoceptor antagonist10.
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KARPPANEN, H., PAAKKARI, I., PAAKKARI, P. et al. Possible involvement of central histamine H2-receptors in the hypotensive effect of clonidine. Nature 259, 587–588 (1976). https://doi.org/10.1038/259587a0
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DOI: https://doi.org/10.1038/259587a0
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