Abstract
RECENT studies have indicated that antiviral action of interferon is triggered by interaction with the cell membrane: Sepharose-bound mouse interferon (IF–Sepharose) retains its antiviral activity, and direct contact with the target cells is necessary to produce the antiviral effect1,2. Cells stimulated by double-stranded polyriboinosinic-polyribocytidylic acid to produce interferon are not protected from viral infection in the presence of interferon antiserum, indicating that interferon acts only after it has left the cells in which it is produced3. The same conclusion has been drawn from experiments with ouabain which inhibits the action, but not the production of primate interferon: cells stimulated to produce interferon fail to become antiviral in the presence of ouabain4.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Ankel, H., Chany, C., Galliot, B., Chevalier, M. J., and Robert, M., Proc. natn. Acad. Sci. U.S.A., 70, 2360–2363 (1973).
Chany, C., Ankel, H., Galliot, B., Chevalier, M. J., and Grégoire, A., Proc. Soc. exp. Biol Med., 147, 293–299 (1974).
Vengris, V. E., Stollar, B. D., and Pitha, P. M., Virology, 65, 410–417 (1975).
Lebon, P., Moreau, M. C., Cohen, L., and Chany, C., Proc. Soc. exp. Biol. Med., 149, 108–112 (1975).
Besançon, F., and Ankel, H., Nature, 250, 782–785 (1974).
Besançon, F., and Ankel, H., Nature, 252, 478–480 (1974).
Svennerholm, L., J. Neurochem., 10, 613–623 (1963).
Basu, M., Chien, J.-L., and Basu, S., Biochem. biophys. Res. Commun., 60, 1097–1104 (1974).
Chien, J.-L., Williams, T., and Basu, S., J. biol. Chem., 248, 1778–1785 (1973).
Bjorndal, H., Hellerqvist, C. G., Lindberg, B., and Svensson, S., Angew. Chem. Int. Engl., 9, 610–619 (1970).
Sung, S. J., Esselman, W. J., and Sweeley, C. C., J. biol. Chem., 248, 6528–6533 (1973).
Huang, J. W., et al., J. biol. Chem., 249, 4665–4667 (1974).
Davey, M. W., Huang, J. W., Sulkowksi, E., and Carter, W. A., J. biol. Chem., 250, 348–349 (1975).
Kornfeld, R., and Kornfeld, S., J. biol. Chem., 245, 2536–2545 (1970).
Brady, R. O., and Fishman, P. H., Biochim. biophys. Acta, 355, 121–148 (1974).
Hakomori, S.-I., Adv. Cancer Res., 18, 265–315 (1973).
Mora, P. T., Fishman, P. H., Bassin, R. H., Brady, R. O., and McFarland, V. W., Nature new biol., 245, 226–229 (1973).
Brailovsky, C. A., Berman, L. D., and Chany, C., Int. J. Cancer, 4, 194–203 (1969).
Pitha, P. M., Vengris, V. E., and Reynolds, F. H., Proc. ICN-UCLA Winter Conf. molec. cell. Biol. Squaw Valley (in the press).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
BESANCON, F., ANKEL, H. & BASU, S. Specificity and reversibility of interferon ganglioside interaction. Nature 259, 576–578 (1976). https://doi.org/10.1038/259576a0
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1038/259576a0
- Springer Nature Limited
This article is cited by
-
Interferon receptors
In Vitro Cellular & Developmental Biology (1988)
-
Biosynthesis of eukaryotic cell surface glycosphingolipids using solubilized glycosyltransferases
Journal of Biosciences (1985)