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Effect of prostaglandin synthesis on renal function and renin in the dog

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Abstract

THERE is considerable evidence for an interrelationship between the prostaglandin and renin–angiotensin systems in the kidney. Infusion of angiotensin II into the renal arteries of dogs and rabbits releases a vasodilator prostaglandin-like material into the renal vein1–4. It also seems that prostaglandins (PGs) induce renin release in the kidney. Riley and his coworkers5,6 infused PGE1 in to the dog renal artery and observed increases in plasma renin activity (PRA) of renal vein blood and in renin secretion. Elevated PRA was observed in blood from the inferior vena cava, just above the entrance of the renal vein, after aortic infusions of PGE1 (ref. 7) and infusion of PGE1 and PGA1 in to the stenosed renal arteries of hypertensive dogs, caused an elevation of renal vein renin8. PGE2 was shown to stimulate renin release in a rabbit renal cortex cell suspension9. Indomethacin decreased the PRA of normal and hypertensive rabbits10,11, and prevented the elevation of PRA in rabbits with glycerol-induced acute renal failure12. In contrast, however, Vander13 infused both PGE1 and PGE2 into the dog renal artery and failed to observe an effect on renin output.

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Authors and Affiliations

  1. Department of Physiology and Biophysics, Schools of Medicine and Dentistry, Georgetown University, Washington DC, 20007

    PHILIP M. BOLGER, GILBERT M. EISNER, PETER W. RAMWELL & LAWRENCE M. SLOTKOFF

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  1. PHILIP M. BOLGER
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  2. GILBERT M. EISNER
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  3. PETER W. RAMWELL
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  4. LAWRENCE M. SLOTKOFF
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BOLGER, P., EISNER, G., RAMWELL, P. et al. Effect of prostaglandin synthesis on renal function and renin in the dog. Nature 259, 244–245 (1976). https://doi.org/10.1038/259244a0

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