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Evidence for inhibition of platelet activation in blood by a drug effect on erythrocytes

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Abstract

ADP released from erythrocytes causes adhesion and aggregation of platelets1. This can presumably happen in vivo when circulating red cells undergo haemolysis in pathological conditions2,3, even though ADP is hydrolysed by enzymes present in blood4–7. More important pathologically, as a factor in thrombogenesis, is the possibility that ADP is also released from red cells which are structurally and metabolically normal. ADP might leak from circulating cells undergoing reversible deformations8 which are much increased by abnormal conditions of flow, for example in vessels narrowed by atherosclerosis.

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Authors and Affiliations

  1. Department of Pharmacology, University of Cambridge, Cambridge, CB2 2QD, UK

    G. V. R. BORN

  2. Department of Experimental Medicine, Pharmacia AB, Uppsala, Sweden

    D. BERGQUIST & K.-E. ARFORS

Authors
  1. G. V. R. BORN
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  2. D. BERGQUIST
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  3. K.-E. ARFORS
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BORN, G., BERGQUIST, D. & ARFORS, KE. Evidence for inhibition of platelet activation in blood by a drug effect on erythrocytes. Nature 259, 233–235 (1976). https://doi.org/10.1038/259233a0

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  • DOI: https://doi.org/10.1038/259233a0

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