Abstract
GILMAN and Nirenberg1 have reported that catecholamines induce a striking increase in intracellular cyclic AMP concentration in cultures of rat and human glioma cells. They concluded that this activation of the adenylate cyclase was mediated through the β-adrenergic receptor, since the effect was inhibited by the β-receptor blockers sotalol and dichloroiso-proterenol. Another report2 showed that cultured human glioma cells treated with cyclic AMP derivatives resumed the typical morphology of the normal counterparts, that is, having multiple processes extending from a compact cell body. I have therefore compared the effects of noradrenaline, a β-adrenergic stimulator, on the morphology and cyclic AMP level in rat C6 glioma cells.
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OEY, J. Noradrenaline induces morphological alterations in nucleated and enucleated rat C6 glioma cells. Nature 257, 317–319 (1975). https://doi.org/10.1038/257317a0
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DOI: https://doi.org/10.1038/257317a0
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