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NMR evidence for common tertiary structure base pairs in yeast and E. coli tRNA

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Abstract

ABOUT ten years ago Holley1 and coworkers sequenced the first tRNA and proposed the now famous cloverleaf secondary structure. Since that time about sixty additional tRNAs have been sequenced and all fit the cloverleaf model2. This homology constitutes a strong case for the cloverleaf model and there is now compelling evidence from nuclear magnetic resonance (NMR) studies3 that the clover-leaf model does provide a correct description of the secondary structure of tRNA molecules in solution.

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Authors and Affiliations

  1. Department of Chemistry, University of California, Riverside, California, 92502

    PHILIP H. BOLTON & DAVID R. KEARNS

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  1. PHILIP H. BOLTON
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  2. DAVID R. KEARNS
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BOLTON, P., KEARNS, D. NMR evidence for common tertiary structure base pairs in yeast and E. coli tRNA. Nature 255, 347–349 (1975). https://doi.org/10.1038/255347a0

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  • DOI: https://doi.org/10.1038/255347a0

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