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Histamine release by gastric stimulants

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Abstract

IT is a matter of debate whether histamine in the gastric mucosa acts as a local chemical mediator for other gastric stimulants1–5, and the isolated bullfrog mucosa provides a convenient model for investigation of the question. The preparation responds to gastric stimulants such as pentagastrin, acetylcholine and histamine; the secretory rate can be monitored easily and there are no complicating factors such as changes in blood flow. Nevertheless, conflicting reports have appeared: Davidson et al.6 found no changes in histamine content after addition of a gastrin-like pentapeptide, while Kasbekar et al.7 showed that pentagastrin and acetylcholine increased the efflux of labelled histamine. I have now used a more direct approach and found that histamine is released in response to pentagastrin and acetylcholine for which it seems to be a common mediator.

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Author notes

  1. P. K. RANGACHARI

    Present address: Physiologie et Pharmacologie, INSERM U7, Hôpital Necker, 161 Rue de Sèvres, 75015, Paris, France

Authors and Affiliations

  1. Cardiovascular Research Institute, University of California School of Medicine, San Francisco, California, 94143

    P. K. RANGACHARI

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  1. P. K. RANGACHARI
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RANGACHARI, P. Histamine release by gastric stimulants. Nature 253, 53–55 (1975). https://doi.org/10.1038/253053a0

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