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Echinomycin: a bifunctional intercalating antibiotic

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Abstract

The interaction between echinomycin and circular DNA or sonicated rod-like DNA fragments shows that this antibiotic binds by a bifunctional mode of intercalation. Binding parameters for a variety of natural and synthetic DNAs vary widely, indicating that echinomycin interacts selectively with specific nucleotide sequences.

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Authors and Affiliations

  1. Department of Pharmacology, Medical School, Hills Road, Cambridge, CB2 2QD, UK

    M. J. Waring & L. P. G. Wakelin

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  1. M. J. Waring
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  2. L. P. G. Wakelin
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Waring, M., Wakelin, L. Echinomycin: a bifunctional intercalating antibiotic. Nature 252, 653–657 (1974). https://doi.org/10.1038/252653a0

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  • DOI: https://doi.org/10.1038/252653a0

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