Abstract
TISSUES from patients with Duchenne muscular dystrophy1 (DMD) as well as animals with similar inherited2 or experimentally produced3 disorders have been shown to undergo significant changes in the amount and composition of their membrane lipids. Most pronounced are the increases in cholesterol and sphingomyelin and the decrease in phosphatidyl choline levels. Functional anomalies observed in this disease, such as the impairment in sarcoplasmic reticulum calcium uptake4 or the changes in the ATPase activity of the sarcolemma5, can be related to the lipid disorder.
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RODAN, S., HINTZ, R., SHA'AFI, R. et al. The activity of membrane bound enzymes in muscular dystrophic chicks. Nature 252, 589–591 (1974). https://doi.org/10.1038/252589a0
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DOI: https://doi.org/10.1038/252589a0
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