Abstract
The represser binding capacity of λplac DNA was maximally reduced by as few as 2–5 cuts by either of two single-strand specific nucleases. But approximately 300 cuts by three nonspecific nicking agents were necessary to give the same effect.
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Chan, H., Wells, R. Structural uniqueness of lactose operator. Nature 252, 205–209 (1974). https://doi.org/10.1038/252205a0
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DOI: https://doi.org/10.1038/252205a0
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