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Cyclic expression of a growth conditioning factor (MGF) on the cell surface

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Abstract

THE cell surface has been implicated as a regulation site for cell division in various systems. Enzymatic alteration of the cell surface can initiate DNA synthesis in contact inhibited cells1–3 and changes in membrane components have been correlated with the expression of the transformed phenotype4–10 and with the entry into the S phase of normal cells11. We describe here a system in which the induction into DNA synthesis of a non-dividing cell population is regulated by a factor exteriorised only during the S and mitosis periods at the surface of the producer cells.

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Author notes

  1. VITTORIO DEFENDI

    Present address: Department of Pathology, New York University Medical Center, New York, New York, 10016

Authors and Affiliations

  1. The Wistar Institute of Anatomy and Biology, 36th Street at Spruce, Philadelphia, Pennsylvania, 19104

    MARIA CIFONE & VITTORIO DEFENDI

Authors
  1. MARIA CIFONE
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  2. VITTORIO DEFENDI
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CIFONE, M., DEFENDI, V. Cyclic expression of a growth conditioning factor (MGF) on the cell surface. Nature 252, 151–153 (1974). https://doi.org/10.1038/252151a0

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  • DOI: https://doi.org/10.1038/252151a0

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