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Stimulation of ribosome synthesis during retarded ageing of human fibroblasts by hydrocortisone

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Abstract

CORTISONE1 and hydrocortisone2 can prolong the lifespan of human embryonic fibroblasts cultivated in vitro and this prolongation is accompanied by a significant increase in the saturation density. The same effect has been observed in cultures of primary human amnion cells3. One of the constant features during senescence in vitro of cells from different species is the progressive decrease of the cell density at which growth practically stops, and it has been suggested4 that the two phenomena, ageing in vitro and decrease of the saturation density, are related.

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Authors and Affiliations

  1. Institut de Cancérologie et d'Immunogénétique de l'INSERM, 94800, Villejuif, France

    A. MACIEIRA-COELHO & E. LORIA

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  1. A. MACIEIRA-COELHO
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  2. E. LORIA
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MACIEIRA-COELHO, A., LORIA, E. Stimulation of ribosome synthesis during retarded ageing of human fibroblasts by hydrocortisone. Nature 251, 67–69 (1974). https://doi.org/10.1038/251067a0

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