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Circadian Variations in Cellular Composition of Lymphoid Organs in Rats with Experimental Endomyometritis

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Circadian variations in the cellular composition of the lymphoid organs were studied in female Wistar rats under normal conditions and in experimental endomyometritis. The fractions of CD8+ cells (effector killers), CD25+ cells (activated/immature lymphocytes), as well as large, medium, small lymphocytes and monocytes/macrophages were assessed at 10.00 and 20.00 h. In the thymus and spleen of rats with endomyometritis, the number of parameters demonstrating significant circadian variations was lower than in intact animals. In the lymph nodes, morning/evening differences appeared for the number of CD8+ and CD25+ cells and monocytes/macrophages in the para-aortic lymph nodes, the number of large and small lymphocytes and CD8+ cells in inguinal lymph nodes, and in the number of large lymphocytes, CD8+ cells, and monocytes/macrophages in the ileal lymph nodes. Thus, the development of chronic inflammation in the uterine and vaginal mucosa was accompanied by desynchronosis in the immune system. Hence, circadian rhythms should be taken into consideration in the diagnosis and treatment of the disease.

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References

  1. Drogovoz SM, Timofeyev MP, Kalko KO. Biological rhythms as markers of the gastrointestinal tract function. Ukr. Biofarm. Zh. 2013;(2):4-8. Russian.

    Google Scholar 

  2. Labunets IF, Grinevich YuA. Biological rhythms of immune system functions and possibilities of their regulation in patients with malignant neoplasms (review of published reports and results of own research). Klin. Onkol. 2014;(2):46-52. Russian.

    Google Scholar 

  3. Litvinenko GI, Shurlygina AV, Shirinskii VS, Nepomnyashchikh VM, Shirinskii IV, Leonova MI, Krugleeva OL, Grigoryeva AE, Kozlov VA, Trufakin VA. Circadian variations in immune values and serum melatonin in asthmatics. Bull. Exp. Biol. Med. 2006;142(5):605-608. doi: https://doi.org/10.1007/s10517-006-0430-7

    Article  CAS  PubMed  Google Scholar 

  4. Starkova EV, Dergacheva TI, Astashov VV. Patent RU No. 2142163. Method for modelling inflammatory diseases in female genital organs. Published November 27, 1999.

  5. Pukhalsky AL, Shmarina GV, Kapranov NI. Anti-inflammatory and immunomoduling effects of macrolides. Immunologiya. 2004;25(6):379-383. Russian.

    Google Scholar 

  6. Trufakin VA, Shurlygina AV, Michurina SV. Lymphoid system — circadian temporary organization and desynchronosis. Byull. Sib. Otdel. Ross. Akad. Med. Nauk. 2012;32(1):5-12. Russian.

    Google Scholar 

  7. Baez NS, Cerbán F, Savid-Frontera C, Hodge DL, Tosello J, Acosta-Rodriguez E, Almada L, Gruppi A, Viano ME, Young HA, Rodriguez-Galan MC. Thymic expression of IL-4 and IL-15 after systemic inflammatory or infectious Th1 disease processes induce the acquisition of “innate” characteristics during CD8+ T cell development. PLoS Pathog. 2019. Vol, 15(1). e1007456. doi: https://doi.org/10.1371/journal.ppat.1007456

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  8. Coiffard B, Leone M, Mege JL. Reply to “Circadian Rhythm Disruption and Sepsis in Severe Trauma Patients”. Shock. 2019;52(6):642. doi: https://doi.org/10.1097/SHK.0000000000001331

  9. Goyal M, Goel A, Bhattacharya S, Verma N, Tiwari S. Circadian variability in airways characteristics: A spirometric study. Chronobiol. Int. 2019;36(11):1550-1557. doi: https://doi.org/10.1080/07420528.2019.1659291

    Article  PubMed  Google Scholar 

  10. Klerman EB. Clinical aspects of human circadian rhythms. J. Biol. Rhythms. 2005;20(4):375-386.

    PubMed  Google Scholar 

  11. Nakai A, Hayano Y, Furuta F, Noda M, Suzuki K. Control of lymphocyte egress from lymph nodes through β2-adrenergic receptors. J. Exp. Med. 2014;211(13):2583-2598. doi: https://doi.org/10.1084/jem.20141132

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  12. Prior KF, O’Donnell AJ, Rund SSC, Savill NJ, van der Veen DR, Reece SE. Host circadian rhythms are disrupted during malaria infection in parasite genotype-specific manners. Sci. Rep. 2019;9(1):10905. doi: https://doi.org/10.1038/s41598-019-47191-8

  13. Shimba A, Cui G, Tani-Ichi S, Ogawa M, Abe S, Okazaki F, Kitano S, Miyachi H, Yamada H, Hara T, Yoshikai Y, Nagasawa T, Schütz G, Ikuta K. Glucocorticoids Drive Circadian Oscillations in T Cell Distribution and Responses by Inducing Interleukin-7 Receptor and CXCR4. Immunity. 2018;48(2):286-298.e6. doi: https://doi.org/10.1016/j.immuni.2018.01.004

    Article  CAS  PubMed  Google Scholar 

  14. Straub RH, Cutolo M. Glucocorticoids and chronic inflammation. Rheumatology (Oxford). 2016;55(Suppl 2):ii6-ii14.

    PubMed  Google Scholar 

  15. Suzuki K, Hayano Y, Nakai A, Furuta F, Noda M. Adrenergic control of the adaptive immune response by circadian lymphocyte recirculation through lymph nodes. J. Exp. Med. 2016;213(12):2567-2574.

    CAS  PubMed  PubMed Central  Google Scholar 

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Authors and Affiliations

  1. Research Institute of Clinical and Experimental Lymphology — Affiliated Branch of Federal Research Center Institute of Cytology and Genetics, Siberian Division of Russian Academy of Sciences, Novosibirsk, Russia

    A. M. Abdalova, A. V. Shurlygina, T. I. Dergacheva, V. V. Klimontov & A. Yu. Letyagin

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  1. A. M. Abdalova
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  2. A. V. Shurlygina
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  3. T. I. Dergacheva
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  4. V. V. Klimontov
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  5. A. Yu. Letyagin
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Correspondence to A. V. Shurlygina.

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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 169, No. 6, pp. 682-686, June, 2020

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Abdalova, A.M., Shurlygina, A.V., Dergacheva, T.I. et al. Circadian Variations in Cellular Composition of Lymphoid Organs in Rats with Experimental Endomyometritis. Bull Exp Biol Med 169, 742–746 (2020). https://doi.org/10.1007/s10517-020-04969-5

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  • DOI: https://doi.org/10.1007/s10517-020-04969-5

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