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Chelating agents for the binding of metal ions to macromolecules

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Abstract

POLYAMINOCARBOXYLATE chelating agents such as ethylene-diaminetetraacetic acid (EDTA) form stable chelate complexes with the ions of many heavy metals. These metal ions exhibit a wide range of useful spectral and radioactive properties, such as electronic absorption, scattering of electrons and X rays, electron paramagnetic resonance spectra, the production of line-broadening and chemical shifts in nuclear magnetic resonance spectra, the emission of correlated gamma-ray cascades and various radioactive lifetimes and nuclear radiations. The preparation of chelating agents whose complexes can interact, in some selected manner, with biological macromolecules could make possible several new applications of metal ions as probes of biological systems.

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References

  1. Meares, C. F., Sundberg, M. W., and Baldeschwieler, J. D., Proc. natn. Acad. Sci. U.S.A., 69, 3718–3722 (1972).

    Article  ADS  CAS  Google Scholar 

  2. Vogel, A. I., Practical organic chemistry, 567–568 (Longmans, Green, New York, 1948).

    Google Scholar 

  3. Blombäck, B., and Blombäck, M., Ark. Kemi., 10, 415–443 (1956).

    Google Scholar 

  4. Marshall, A. G., Werbelow, L. G., and Meares, C. F., J. chem. Phys., 57, 364–370 (1972). Erratum: page 4508.

    Article  ADS  CAS  Google Scholar 

  5. Rockwell, S. C., Kallman, R. F., and Fajardo, L. F., J. natn. Cancer Inst., 49, 735–749 (1972).

    CAS  Google Scholar 

  6. Goodwin, D. A., Finston, R. A., Colombetti, L. G., Beaver, J. E., and Hupf, H., J. nucl. Med., 10, 337 (1969).

    Google Scholar 

  7. Hunter, W. W., and de Kock, H. W., J. nucl. Med., 10, 343 (1969).

    Google Scholar 

  8. Goodwin, D. A., Meares, C. F., and Song, C. H., Radiology, 105, 699–702 (1972).

    Article  CAS  Google Scholar 

  9. Meares, C. F., et al., J. med. Chem. (in the press).

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Author notes

  1. M. W. SUNDBERG

    Present address: Research Laboratories, Eastman Kodak Co., Rochester, New York, 14650

Authors and Affiliations

  1. Chemistry Department, Stanford University, Stanford, California, 94305

    M. W. SUNDBERG

  2. Chemistry Department, University of California, Davis, California, 95616

    C. F. MEARES

  3. Veterans Administration Hospital, Palo Alto, California, 94304

    D. A. GOODWIN & C. I. DIAMANTI

Authors
  1. M. W. SUNDBERG
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  2. C. F. MEARES
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  3. D. A. GOODWIN
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  4. C. I. DIAMANTI
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SUNDBERG, M., MEARES, C., GOODWIN, D. et al. Chelating agents for the binding of metal ions to macromolecules. Nature 250, 587–588 (1974). https://doi.org/10.1038/250587a0

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