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A phenylethylamine oxidising defect in migraine

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Abstract

FOR some two hundred years, certain foodstuffs have been known to trigger migraine attacks1. In 1967, knowing that cheese is a common dietary trigger to migraine, Hanington2 fed tyramine, which it is known to contain, to affected subjects and by this action was able to initiate headache episodes.

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References

  1. Fothergill, J., Medical Observations and Enquiries, 6, 103–137 (1784).

    Google Scholar 

  2. Hanington, E., Br. med. J., 2, 550–551 (1967).

    Article  Google Scholar 

  3. Hanington, E., Horn, M., and Wilkinson, M., in Background to Migraine: Third Migraine Symposium (edit. by Cochrane, A. L.), 113–119 (Heinemann, London, 1970).

    Google Scholar 

  4. Sandler, M., Lancet, i, 618–619 (1972).

    Article  Google Scholar 

  5. Alabaster, V. A., and Bakhle, Y. S., Br. J. Pharmac., 40, 582P–583P (1970).

    Article  CAS  Google Scholar 

  6. Sandler, M., Headache (in the press).

  7. Bakhle, Y. S., and Smith, T. W., Br. J. Pharmac., 46, 543P–544P (1973).

    Google Scholar 

  8. Edwards, D. J., and Blau, K., Biochem. J., 130, 495–503 (1972); Edwards, D. J., and Blau, K., Biochem. J., 132, 95–100 (1973).

    Article  CAS  Google Scholar 

  9. Sandler, M., Youdim, M. B. H., Southgate, J., and Hanington, E., in Background to Migraine. Third Migraine Symposium. (edit. by Cochrane, A. L.), 103–112 (Heinemann, London, 1970).

    Google Scholar 

  10. Sicuteri, F., Buffoni, F., Anselmi, B., and Del Bianco, P. L., Res. clin. Stud. Headache, 3, 245–251 (1972).

    Google Scholar 

  11. Johnson, J. P., Biochem. Pharmac., 17, 1285–1297 (1968).

    Article  Google Scholar 

  12. Goridis, C., and Neff, N. H., Proc. Soc. exp. Biol. Med., 140, 573–574 (1972).

    Article  CAS  Google Scholar 

  13. McCauley, R., and Racker, E., Molec. cell. Biochem., 1, 73–81 (1973).

    Article  CAS  Google Scholar 

  14. Goridis, C., and Neff, N. H., Br. J. Pharmac., 43, 814–818 (1971).

    Article  CAS  Google Scholar 

  15. Neff, N. H., Adv. biochem. Psychopharmac. (in the press).

  16. Yang, H.-Y. T., and Neff, N. H., J. Pharmac. exp. Ther., 187, 365–371 (1973).

    CAS  Google Scholar 

  17. Collins, G. G. S., and Sandler, M., Biochem. Pharmac., 20, 289–296 (1971).

    Article  CAS  Google Scholar 

  18. Robinson, D. S., Lovenberg, W., Keiser, H., and Sjoerdsma, A., Biochem. Pharmac., 17, 109–119 (1968).

    Article  CAS  Google Scholar 

  19. Tipton, K. F., Houslay, M. D., and Garrett, N. J., Nature new Biol., 246, 213–214 (1973).

    Article  CAS  Google Scholar 

  20. Youdim, M. B. H., Holzbauer, M., and Woods, H. F., Adv. biochem. Psychopharmac. (in the press).

  21. Collins, G. G. S., Sandler, M., Williams, E. D., and Youdim, M. B. H., Nature, 225, 817–820 (1970).

    Article  ADS  CAS  Google Scholar 

  22. Bakhle, Y. S., and Smith, T. W., Br. J. Pharmac. (in the press).

  23. Vane, J. R., Br. J. Pharmac., 35, 209–242 (1969).

    Article  CAS  Google Scholar 

  24. Lowry, O. H., Rosebrough, N. J., Farr, A. L., and Randall, R. J., J. biol. Chem., 193, 265–275 (1951).

    CAS  Google Scholar 

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SANDLER, M., YOUDIM, M. & HANINGTON, E. A phenylethylamine oxidising defect in migraine. Nature 250, 335–337 (1974). https://doi.org/10.1038/250335a0

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