Skip to main content

Advertisement

SpringerLink
Log in

Reduced axoplasmic transport of choline acetyltransferase activity in dystrophic mice

  • Letter
  • Published:

From Nature

View current issue Submit your manuscript

Abstract

MUSCULAR dystrophy has been regarded as a “primary degenerative myopathy”1. But there is evidence from studies of both human muscular dystrophy and animal models of muscular dystrophy that the muscle disease may have a neural basis2. The mechanism of the suspected neural disorder remains to be elucidated. Since there is independent evidence that in normal animals the trophic effect of nerve on muscle depends on intact axoplasmic transport3, we have initiated a study of axoplasmic transport in dystrophic mice. We have found a disturbance of axoplasmic transport of choline acetyltransferase activity in dystrophic mice.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Walton, J. N., Br. Med. J., 1, 1271–1274, 1344–1348 (1967).

    Article  Google Scholar 

  2. Gallup, B., and Dubowitz, V., Nature, 243, 287–289 (1973).

    Article  ADS  CAS  Google Scholar 

  3. Albuquerque, E. X., Warnick, J. E., Tasse, J. R., and Sansone, F. M., Expl Neurol., 37, 607–634 (1972).

    Article  CAS  Google Scholar 

  4. Hebb, C., Physiol. Rev., 52, 918–957 (1972).

    Article  CAS  Google Scholar 

  5. Kása, P., Mann, S. P., and Hebb, C., Nature, 226, 814–816 (1970).

    Article  ADS  Google Scholar 

  6. Hebb, C. O., and Waites, G. M. H., J. Physiol., Lond., 132, 667–671 (1956).

    Article  CAS  Google Scholar 

  7. Hebb, C. O., and Silver, A., J. Physiol., Lond, 169, 41P–42P (1963).

    Google Scholar 

  8. Kása, P., Mann, S. P., Karcsu, S., Tóth, L., and Jordan, S., J. Neurochem., 21, 431–436 (1973).

    Article  Google Scholar 

  9. Wooten, G. F., and Coyle, J. T., J. Neurochem., 20, 1361–1372 (1973).

    Article  CAS  Google Scholar 

  10. Oesch, F., Otten, U., and Thoenen, H., J. Neurochem., 20, 1691–1706 (1973).

    Article  CAS  Google Scholar 

  11. Saunders, N. R., Dziegielewska, K., Häggendal, C. J., and Dahlström, A. B., J. Neurobiol., 4, 95–103 (1973).

    Article  CAS  Google Scholar 

  12. Michelson, A. M., Russell, E. S., and Harman, P. J., Proc. natn. Acad. Sci. U.S.A., 41, 1079–1084 (1955).

    Article  ADS  CAS  Google Scholar 

  13. Brimijoin, S., J. Neurochem., 19, 2183–2193 (1972).

    Article  CAS  Google Scholar 

  14. Lowry, O. H., Rosebrough, N. J., Farr, A. L., and Randall, R. J., J. biol. Chem., 193, 265–275 (1951).

    CAS  Google Scholar 

  15. Bradley, W. G., and Jaros, E., Brain, 96, 247–258 (1973).

    Article  CAS  Google Scholar 

  16. McComas, A. J., and Mossawy, S. J., Research in Muscular Dystrophy (3rd Symposium on Muscular Dystrophy, London, 1965) pp. 317–341.

    Google Scholar 

  17. Harris, J. B., and Wilson, P., J. neurol. Neurosurg. Psychiat., 34, 512–520 (1971).

    Article  CAS  Google Scholar 

  18. Harris, J. B., Wallace, C., and Wing, J., J. neurol. Sci., 15, 245–249 (1972).

    Article  CAS  Google Scholar 

  19. Bradley, W. G., and Jenkison, M., J. neurol. Sci., 18, 227–247 (1973).

    Article  CAS  Google Scholar 

  20. Salafsky, B., and Stirling, C. A., Nature, 246, 126–128 (1973).

    Article  CAS  Google Scholar 

  21. Salafsky, B., Nature, 229, 270–273 (1971).

    Article  ADS  CAS  Google Scholar 

  22. Fonnum, F., Frizell, M., and Sjöstrand, J., J. Neurochem., 21, 1109–1120 (1973).

    Article  CAS  Google Scholar 

  23. Giller, E. J., jun., Schrier, B. K., Shainberg, A., Fisk, H. R., and Nelson, P. G., Science, 182, 588–589 (1973).

    Article  ADS  CAS  Google Scholar 

  24. McCaman, M. W., Stafford, M. L., and Skinner, E. C., Am. J. Physiol., 212, 228–232 (1967).

    CAS  PubMed  Google Scholar 

  25. Glover, V., and Green, D. P. L., J. Neurochem., 19, 2465–2466 (1972).

    Article  CAS  Google Scholar 

  26. Feigenson, M. E., and Saelens, J. K., Biochem. Pharmac., 18, 1479–1486 (1969).

    Article  CAS  Google Scholar 

  27. Potter, L. T., Glover, V. A. S., and Saelens, J. K., J. biol. Chem., 243, 3864–3870 (1968).

    CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Departments of Neurology and Pharmacology, Mayo Clinic, Rochester, Minnesota, 55901

    CHARLES JABLECKI & STEPHEN BRIMIJOIN

Authors
  1. CHARLES JABLECKI
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. STEPHEN BRIMIJOIN
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

JABLECKI, C., BRIMIJOIN, S. Reduced axoplasmic transport of choline acetyltransferase activity in dystrophic mice. Nature 250, 151–154 (1974). https://doi.org/10.1038/250151a0

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1038/250151a0

  • Springer Nature Limited

This article is cited by

Search

Navigation