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New biological activity following intravascular activation of the complement cascade

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Abstract

ACTIVATION of the complement cascade (C1–C9) by the classic or alternate pathways is associated with the development of several biological activities1. These include the elaboration of chemotactic factors (C3a, C5a, and a trimolecular complex C&5,6,7bar;), opsonic activity associated with the formation of C3b from the third component, anaphylatoxin activity associated with the formation of C3a and C5a from the third (C3) and fifth (C5) components, and lysis of certain cells after the formation of lesions at the cell surface associated with fixation of the eighth (C8) and ninth (C9) components. We have detected another activity which follows intravascular activation of the complement cascade with the elaboration of the low molecular weight factor that produces an immediate neutropenia followed by marked neutrophilia.

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Authors and Affiliations

  1. Bowman Gray School of Medicine, Wake, Forest University, Winston-Salem, North Carolina, 27103

    CHARLES E. MCCALL & LAWRENCE R. DE CHATELET

  2. Royal Postgraduate Medical School, London, W12, UK

    DAVID BROWN & PETER LACHMANN

Authors
  1. CHARLES E. MCCALL
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  2. LAWRENCE R. DE CHATELET
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  3. DAVID BROWN
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  4. PETER LACHMANN
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MCCALL, C., DE CHATELET, L., BROWN, D. et al. New biological activity following intravascular activation of the complement cascade. Nature 249, 841–843 (1974). https://doi.org/10.1038/249841a0

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  • DOI: https://doi.org/10.1038/249841a0

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