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Subunit structure of H-2 alloantigens

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Abstract

HISTOCOMPATIBILITY antigens carry the immunological determinants involved in tissue transplant rejection1. Recent evience has shown that papain-solubilised HL-A antigens are composed of two polypeptide chains2,3. The smaller of the solubilised HL-A polypeptide chains has been shown4,5 to be identical to β2-microglobulin and it has also been shown that β2-microglobulin is physically linked to the HL-A antigens on the cell surface6–9. These findings raised the question of whether the major transplantation antigens from other species are composed of subunits. This communication shows that mouse H-2 alloantigens are linked to a small polypeptide chain which is homologous with human β2-microglobulin.

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Authors and Affiliations

  1. Institute of Medical Chemistry, Biomedical Centre and the Blood Centre, University of Uppsala, Uppsala, Sweden

    LARS RASK, J. BERTIL LINDBLOM & PER A. PETERSON

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  1. LARS RASK
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  2. J. BERTIL LINDBLOM
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  3. PER A. PETERSON
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RASK, L., LINDBLOM, J. & PETERSON, P. Subunit structure of H-2 alloantigens. Nature 249, 833–834 (1974). https://doi.org/10.1038/249833a0

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