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Natural resistance to Salmonella infection, delayed hypersensitivity and Ir genes in different strains of mice

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Abstract

THE development of immunity to an intracellular bacterial infection such as that produced by Salmonella typhimurium in mice can be followed by the fall in the numbers of living bacteria in the liver and spleen. Resistance to infection appears at about the same time as delayed hypersensitivity to appropriate antigens of the infecting organisms and both may be taken as indicators of a cell-mediated immune response1. Inbred mouse strains differ widely in their resistance to salmonella infections and one possible explanation is that they differ in their ability to produce cell-mediated immune responses in general. This has been tested by comparing the degrees of delayed hypersensitivity detectable in different strains of mice sensitised with a number of unrelated antigens. The results discussed here disprove the hypothesis but suggest a more interesting one.

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Authors and Affiliations

  1. Bacteriology Department, St Mary's Hospital Medical School, Paddington, London, W2

    J. PLANT & A. A. GLYNN

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  1. J. PLANT
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  2. A. A. GLYNN
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PLANT, J., GLYNN, A. Natural resistance to Salmonella infection, delayed hypersensitivity and Ir genes in different strains of mice. Nature 248, 345–347 (1974). https://doi.org/10.1038/248345a0

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  • DOI: https://doi.org/10.1038/248345a0

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